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A systematic review and meta-analysis of the factors associated with nonadherence and discontinuation of statins among people aged ≥65 Years

Ofori-Asenso, R, Jakhu, A, Curtis, AJ, Zomer, E, Gambhir, M, Jaana Korhonen, M, Nelson, M ORCID: 0000-0001-9941-7161, Tonkin, A, Liew, D and Zoungas, S 2018 , 'A systematic review and meta-analysis of the factors associated with nonadherence and discontinuation of statins among people aged ≥65 Years' , Journals of Gerontology. Series A: Biological Sciences and Medical Sciences , pp. 1-8 , doi: 10.1093/gerona/glx256.

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Abstract

Background: Older individuals (aged ≥65 years) are commonly prescribed statins but may experience a range of barriers in adhering to therapy. The factors associated with poor statin adherence and/or discontinuation among this population have not been comprehensively reviewed.Methods: We conducted a systematic review to identify English articles published through December 12, 2016 that reported factors associated with nonadherence and/or discontinuation of statins among older persons. Data were pooled via random-effects meta-analysis techniques.Results: Forty-five articles reporting data from more than 1.8 million older statin users from 13 countries were included. The factors associated with increased statin nonadherence were black/non-white race (odds ratio [OR] 1.66, 95% confidence interval [CI] 1.39-1.98), female gender (OR 1.08, 95% CI 1.03-1.13), current smoker (OR 1.12, 95% CI 1.03-1.21), higher copayments (OR 1.38, 95% CI 1.25-1.52), new user (OR 1.58, 95% CI 1.21-2.07), lower number of concurrent cardiovascular medications (OR 1.08, 95% CI 1.06-1.09), primary prevention (OR 1.49, 95% CI 1.40-1.59), having respiratory disorders (OR 1.17, 95% CI 1.12-1.23) or depression (OR 1.11, 95% CI 1.06-1.16), and not having renal disease (OR 1.09, 95% CI 1.04-1.14). The factors associated with increased statin discontinuation were lower income status (OR 1.20, 95% CI 1.06-1.36), current smoker (OR 1.14, 95% CI 1.06-1.23), higher copayment (OR 1.61, 95% CI 1.53-1.70), higher number of medications (OR 1.04, 95% CI 1.01-1.06), presence of dementia (OR 1.18, 95% CI 1.02-1.36), cancer (OR 1.22, 95% CI 1.11-1.33) or respiratory disorders (OR 1.19, 95% CI 1.05-1.34), primary prevention (OR 1.66, 95% CI 1.24-2.22), and not having hypertension (OR 1.13, 95% CI 1.07-1.20) or diabetes (OR 1.09, 95% CI 1.04-1.15).Conclusion: Interventions that target potentially modifiable factors including financial and social barriers, patients' perceptions about disease risk as well as polypharmacy may improve statin use in the older population.

Item Type: Article
Authors/Creators:Ofori-Asenso, R and Jakhu, A and Curtis, AJ and Zomer, E and Gambhir, M and Jaana Korhonen, M and Nelson, M and Tonkin, A and Liew, D and Zoungas, S
Keywords: adherence, HMG-CoA reductase inhibitors, persistence, risk indicators
Journal or Publication Title: Journals of Gerontology. Series A: Biological Sciences and Medical Sciences
Publisher: Gerontological Society Amer
ISSN: 1079-5006
DOI / ID Number: 10.1093/gerona/glx256
Copyright Information:

Copyright 2018 the authors.

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