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A Novel Y-Specifc Long NonCoding RNA Associated with Cellular Lipid Accumulation in HepG2 cells and Atherosclerosisrelated Genes

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Molina, E, Chew, GS, Myers, SA ORCID: 0000-0003-4793-3820, Clarence, EM, Eales, JM, Tomaszewski, M and Carchar, FJ 2017 , 'A Novel Y-Specifc Long NonCoding RNA Associated with Cellular Lipid Accumulation in HepG2 cells and Atherosclerosisrelated Genes' , Scientific Reports, vol. 7 , pp. 1-12 , doi: 10.1038/s41598-017-17165-9.

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Abstract

There is an increasing appreciation for the role of the human Y chromosome in phenotypic diferencesbetween the sexes in health and disease. Previous studies have shown that genetic variation withinthe Y chromosome is associated with cholesterol levels, which is an established risk factor foratherosclerosis, the underlying cause of coronary artery disease (CAD), a major cause of morbidityand mortality worldwide. However, the exact mechanism and potential genes implicated are stillunidentifed. To date, Y chromosome-linked long non-coding RNAs (lncRNAs) are poorly characterizedand the potential link between these new regulatory RNA molecules and hepatic function in men hasnot been investigated. Advanced technologies of lncRNA subcellular localization and silencing wereused to identify a novel intergenic Y-linked lncRNA, named lnc-KDM5D-4, and investigate its role infatty liver-associated atherosclerosis. We found that lnc-KDM5D-4 is retained within the nucleus inhepatocytes. Its knockdown leads to changes in genes leading to increased lipid droplets formationin hepatocytes resulting in a downstream efect contributing to the chronic infammatory processthat underpin CAD. Our fndings provide the frst evidence for the implication of lnc-KDM5D-4 in keyprocesses related to fatty liver and cellular infammation associated with atherosclerosis and CAD inmen.

Item Type: Article
Authors/Creators:Molina, E and Chew, GS and Myers, SA and Clarence, EM and Eales, JM and Tomaszewski, M and Carchar, FJ
Keywords: Non coding RNA, cardiovascular diisease
Journal or Publication Title: Scientific Reports
Publisher: Nature Publishing Group
ISSN: 2045-2322
DOI / ID Number: 10.1038/s41598-017-17165-9
Copyright Information:

© The Author(s) 2017. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

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