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Raised FGF-21 and Triglycerides Accompany Increased Energy Intake Driven by Protein Leverage in Lean, Healthy Individuals: A Randomised Trial

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Gosby, AK, Lau, NS, Tam, CS, Iglesias, MA ORCID: 0000-0001-5781-2091, Morrison, CD, Caterson, ID, Brand-Miller, J, Conigrave, AD, Raubenheimer, D and Simpson, SJ 2018 , 'Raised FGF-21 and Triglycerides Accompany Increased Energy Intake Driven by Protein Leverage in Lean, Healthy Individuals: A Randomised Trial' , PloS one, vol. 11, no. 8 , pp. 1-16 , doi: 10.1371/journal.pone.0161003.

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Abstract

A dominant appetite for protein drives increased energy intake in humans when the proportion of protein in the diet is reduced down to approximately 10% of total energy. Compensatory feeding for protein is apparent over a 1–2 d period but the mechanisms driving this regulation are not fully understood. Fibroblast growth factor-21 (FGF-21) has been identified as a candidate protein signal as levels increase in the circulation when dietary protein is low. The aim of this randomised controlled trial was to assess whether changes in percent dietary protein over a 4 d ad libitum experimental period in lean, healthy participants influenced energy intake, metabolic health, circulating FGF-21 and appetite regulating hormones including ghrelin, glucagon like peptide-1 and cholecystokinin. Twenty-two lean, healthy participants were fed ad libitum diets containing 10, 15 and 25% protein, over three, 4 d controlled, in-house experimental periods. Reduced dietary protein intake from 25% to 10% over a period of 4 d was associated with 14% increased energy intake (p = 0.02) as previously reported, and a 6-fold increase in fasting circulating plasma FGF-21 levels (pad libitum in-house feeding period and may be important in regulation of dietary protein intake.

Item Type: Article
Authors/Creators:Gosby, AK and Lau, NS and Tam, CS and Iglesias, MA and Morrison, CD and Caterson, ID and Brand-Miller, J and Conigrave, AD and Raubenheimer, D and Simpson, SJ
Keywords: Protein leverage, obesity, energy intake, human
Journal or Publication Title: PloS one
Publisher: Public Library of Science
ISSN: 1932-6203
DOI / ID Number: 10.1371/journal.pone.0161003
Copyright Information:

Copyright 2016 Gosby et al. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

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