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Carbohydrate and protein intake during exertional-heat stress ameliorates intestinal epithelial injury and small intestine permeability

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Snipe, RMJ, Khoo, A, Kiktic, CM ORCID: 0000-0001-9866-5665, Gibson, P and Costa, RJS 2017 , 'Carbohydrate and protein intake during exertional-heat stress ameliorates intestinal epithelial injury and small intestine permeability' , Applied physiology, nutrition, and metabolism, vol. 42, no. 12 , pp. 1283-1292 , doi: 10.1139/apnm-2017-0361.

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Abstract

Background: Exertional-heat stress (EHS) disturbs the integrity of the gastrointestinal tract leading to endotoxaemia and cytokinaemia, which have symptomatic and health implications. This study aimed to determine the effects of carbohydrate and protein intake during EHS on gastrointestinal integrity, symptoms and systemic responses. Methods: Eleven (male n=6, female n=5) endurance runners completed 2h running at 60% V̇O2max in 35°C ambient temperature on three occasions in randomised order, consuming water (WATER) or 15g glucose (GLUC) or energy-matched whey protein hydrolysate (WPH) before and every 20min during EHS. Rectal temperature and gastrointestinal symptoms were recorded every 10min during EHS. Blood was collected pre- and post-EHS, and during recovery to determine plasma concentrations of intestinal fatty-acid binding protein (I-FABP) as a marker of intestinal epithelial injury, cortisol, endotoxin, and inflammatory cytokines. Urinary lactulose:L-rhamnose was used to measure small intestine permeability. Results: Compared to WATER, GLUC and WPH ameliorated EHS-associated intestinal epithelial injury (I-FABP: 897±478pg·ml-1 vs. 123±197pg·ml-1 and 82±156pg·ml-1, respectively, pConclusion: Carbohydrate and protein intake during EHS ameliorates intestinal injury and permeability. Carbohydrate also supports endotoxin clearance and reduces stress markers, while protein appears to increase gastrointestinal symptoms. Suggesting carbohydrate is a more appropriate option.

Item Type: Article
Authors/Creators:Snipe, RMJ and Khoo, A and Kiktic, CM and Gibson, P and Costa, RJS
Keywords: gastrointestinal, exercise, IFABP
Journal or Publication Title: Applied physiology, nutrition, and metabolism
Publisher: Canadian Science Publishing
ISSN: 1715-5312
DOI / ID Number: 10.1139/apnm-2017-0361
Copyright Information:

Copyright 2017 the Authors

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