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Associations between knee effusion-synovitis and joint structural changes in patients with knee osteoarthritis

Wang, X, Jin, X, Blizzard, L ORCID: 0000-0002-9541-6943, Antony, B ORCID: 0000-0001-8704-6084, Han, W ORCID: 0000-0003-1590-7433, Zhu, Z ORCID: 0000-0003-3913-2564, Cicuttini, F, Wluka, AE, Winzenberg, T ORCID: 0000-0002-4112-3491, Jones, G ORCID: 0000-0002-9814-0006 and Ding, C ORCID: 0000-0002-9479-730X 2017 , 'Associations between knee effusion-synovitis and joint structural changes in patients with knee osteoarthritis' , Journal of Rheumatology, vol. 44, no. 11 , pp. 1644-1651 , doi:

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Objective: To describe the associations between effusion-synovitis and joint structural abnormalities in patients with knee osteoarthritis (OA) over 24 months.Methods: A posthoc analysis using data from a randomized controlled trial in 413 patients with symptomatic OA (aged 63 ± 7 yrs, 208 women). Knee effusion-synovitis volume and score, cartilage defects, cartilage volume, and bone marrow lesions (BML) were assessed using magnetic resonance imaging. Joint space narrowing (JSN) and osteophytes were assessed using radiograph. Least significant change criterion was used to define change in effusion-synovitis volume. Knee symptoms were assessed by Western Ontario and McMaster University OA Index. Multivariable linear/logistic regression and multilevel generalized mixed-effects models were used in longitudinal analyses.Results: Total effusion-synovitis volume increased modestly from baseline (8.0 ± 8.5 ml) to followup (9.0 ± 10.5 ml). Baseline BML, cartilage defect, JSN, and osteophyte scores were positively associated with change in effusion-synovitis volume (p Conclusion: Knee cartilage and subchondral bone abnormalities predicted change in effusion-synovitis, but effusion-synovitis did not predict knee structural changes. These findings suggest that synovial inflammation is likely the result of joint structural abnormalities in established OA.

Item Type: Article
Authors/Creators:Wang, X and Jin, X and Blizzard, L and Antony, B and Han, W and Zhu, Z and Cicuttini, F and Wluka, AE and Winzenberg, T and Jones, G and Ding, C
Keywords: effusion, knee osteoarthritis, magnetic resonance imaging, synovitis
Journal or Publication Title: Journal of Rheumatology
Publisher: J Rheumatol Publ Co
ISSN: 0315-162X
DOI / ID Number:
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The Journal of Rheumatology Copyright © 2017

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