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Abstract

Background: Zinc is a metal ion that is essential for growth and development, immunity, and metabolism, andtherefore vital for life. Recent studies have highlighted zinc’s dynamic role as an insulin mimetic and a cellular secondmessenger that controls many processes associated with insulin signaling and other downstream pathways that areamendable to glycemic control.Main body: Mechanisms that contribute to the decompartmentalization of zinc and dysfunctional zinc transportermechanisms, including zinc signaling are associated with metabolic disease, including type 2 diabetes. Theactions of the proteins involved in the uptake, storage, compartmentalization and distribution of zinc in cells is underintense investigation. Of these, emerging research has highlighted a role for several zinc transporters in the initiation ofzinc signaling events in cells that lead to metabolic processes associated with maintaining insulin sensitivity and thusglycemic homeostasis.Conclusion: This raises the possibility that zinc transporters could provide novel utility to be targeted experimentallyand in a clinical setting to treat patients with insulin resistance and thus introduce a new class of drug target with utilityfor diabetes pharmacotherapy.

Item Type:	Article
Authors/Creators:	Norouzi, S and Adulcikas, J and Sohal, SS and Myers, S
Keywords:	Zinc transporters, Type 2 diabetes, Insulin resistance
Journal or Publication Title:	Journal of Biomedical Science
Publisher:	Karger
ISSN:	1021-7770
DOI / ID Number:	https://doi.org/10.1186/s12929-017-0394-0
Copyright Information:	© 2017 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Related URLs:	Google Scholar: Sohal, SS UTAS Profile: Sohal, SS UTAS Profile: Myers, S
Item Statistics:	View statistics for this item

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