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Urox containing concentrated extracts of Crataeva nurvala stem bark, Equisetum arvense stem and Lindera aggregata root, in the treatment of symptoms of overactive bladder and urinary incontinence: a phase 2, randomised, double-blind placebo controlled trial

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Schoendorfer, N, Sharp, N, Seipel, T, Schauss, AG and Ahuja, KDK ORCID: 0000-0002-0323-4692 2018 , 'Urox containing concentrated extracts of Crataeva nurvala stem bark, Equisetum arvense stem and Lindera aggregata root, in the treatment of symptoms of overactive bladder and urinary incontinence: a phase 2, randomised, double-blind placebo controlled trial' , Bmc Alternative Medicine, vol. 18 , pp. 1-11 , doi: 10.1186/s12906-018-2101-4.

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Abstract

Background: Storage lower urinary tract symptoms (LUTS) including overactive bladder (OAB) and urinary incontinence(UI) affect millions of people worldwide, significantly impacting quality of life. Plant based medicines have beendocumented both empirically and in emerging scientific research to have varying benefits in reducing bladdersymptoms. We assessed the efficacy of Urox®, a proprietary combination of phytomedicine extracts including, Cratevox™(Crataeva nurvala) stem bark, Equisetem arvense stem and Lindera aggregata root, in reducing symptoms of OAB and UI.Methods: Efficacy of the herbal combination on a variety of bladder symptoms compared to an identical placebo, weredocumented in a randomised, double-blind, placebo controlled trial conducted at two primary care centres. Data werecollected at baseline, 2, 4 and 8 weeks, with the primary outcome being self-reported urinary frequency. Statistical analysisincluded mixed effects ordered logistic regression with post hoc Holm’s test to account for repeated measures, andincluded an intention-to-treat analysis.Results: One hundred and fifty participants (59% female, aged; mean ± SD; 63.5 ± 13.1 years) took part in the study. Atweek 8, urinary day frequency was significantly lower (OR 0.01; 95%CI 0.01 to 0.02; p Conclusions: The outcome of this study demonstrated both statistical significance and clinical relevance in reducingsymptoms of OAB, urinary frequency and/or urgency and incontinence. The demonstrated viability of the herbalcombination to serve as an effective treatment, with minimal side-effects, warrants further longer term research andconsideration by clinicians.

Item Type: Article
Authors/Creators:Schoendorfer, N and Sharp, N and Seipel, T and Schauss, AG and Ahuja, KDK
Keywords: urinary, incontinence
Journal or Publication Title: Bmc Alternative Medicine
Publisher: BioMed Central Ltd.
ISSN: 1472-6882
DOI / ID Number: 10.1186/s12906-018-2101-4
Copyright Information:

Copyright 2018 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

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