Open Access Repository

Time to lung aeration during a sustained inflation at birth is influenced by gestation in lambs

Altmetric

McCall, KE, Waldmann, AD, Pereira-Fantini, P, Oakley, R, Miedema, M, Perkins, EJ, Davis, PG, Dargaville, PA, Bohm, SH, Dellaca, R, Sourial, M, Zannin, E, Rajapaksa, AE, Tan, A, Adler, A, Frerichs, I and Tingay, DG 2017 , 'Time to lung aeration during a sustained inflation at birth is influenced by gestation in lambs' , Pediatric Research, vol. 82, no. 4 , pp. 712-720 , doi: https://doi.org/10.1038/pr.2017.141.

Full text not available from this repository.

Official URL: http://dx.doi.org/10.1038/pr.2017.141

Abstract

Background: Current sustained lung inflation (SI) approaches use uniform pressures and durations. We hypothesized that gestational-age-related mechanical and developmental differences would affect the time required to achieve optimal lung aeration, and resultant lung volumes, during SI delivery at birth in lambs.Methods: 49 lambs, in five cohorts between 118 and 139 days of gestation (term 142 d), received a standardized 40 cmH2O SI, which was delivered until 10 s after lung volume stability (optimal aeration) was visualized on real-time electrical impedance tomography (EIT), or to a maximum duration of 180 s. Time to stable lung aeration (Tstable) within the whole lung, gravity-dependent, and non-gravity-dependent regions, was determined from EIT recordings.Results: Tstable was inversely related to gestation (PTstable increased with gestation from a mean (SD) of 20 (17) ml/kg at 118 d to 56 (13) ml/kg at 139 d (P=0.002, one-way ANOVA). There were no gravity-dependent regional differences in Tstable or aeration.Conclusions: The trajectory of aeration during an SI at birth is influenced by gestational age in lambs. An understanding of this may assist in developing SI protocols that optimize lung aeration for all infants.

Item Type:	Article
Authors/Creators:	McCall, KE and Waldmann, AD and Pereira-Fantini, P and Oakley, R and Miedema, M and Perkins, EJ and Davis, PG and Dargaville, PA and Bohm, SH and Dellaca, R and Sourial, M and Zannin, E and Rajapaksa, AE and Tan, A and Adler, A and Frerichs, I and Tingay, DG
Journal or Publication Title:	Pediatric Research
Publisher:	Int Pediatric Research Foundation
ISSN:	0031-3998
DOI / ID Number:	https://doi.org/10.1038/pr.2017.141
Copyright Information:	Copyright 2017 International Pediatric Research Foundation
Related URLs:	UTAS Profile: Dargaville, PA
Item Statistics:	View statistics for this item

Actions (login required)

Item Control Page

TOP