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Geometrical alignment of multiple fabrication steps for rapid prototyping of microfluidic paper-based analytical devices

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Rahbar, M, Nesterenko, PN ORCID: 0000-0002-9997-0650, Paull, B ORCID: 0000-0001-6373-6582 and Macka, M ORCID: 0000-0002-6792-2574 2017 , 'Geometrical alignment of multiple fabrication steps for rapid prototyping of microfluidic paper-based analytical devices' , Analytical Chemistry, vol. 89, no. 22 , pp. 11918-11923 , doi: 10.1021/acs.analchem.7b03796.

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Abstract

Three main fabrication steps for microfluidic paper-based analytical devices (μPADs) were fully integrated with accurate geometrical alignment between the individual steps in a simple and rapid manner. A wax printer for creating hydrophobic barriers was integrated with an inexpensive (ca. $300) electronic craft plotter/cutter for paper cutting, followed by colorimetric reagent deposition using technical pens. The principal shortcoming in the lack of accurate and precise alignment of the features created by these three individual fabrication steps was addressed in this work by developing appropriate alignment procedures during the multistep fabrication process. The wax printing step was geometrically aligned with the following cutting and plotting (deposition) steps in a highly accurate and precise manner using optical scanning function of the plotter/cutter based on registration marks printed on the paper using the wax printer and scanned by the plotter/cutter. The accuracy and precision of alignment in a two-dimensional plane were quantified by cutting and plotting cross-shaped features and measuring their center coordinates relative to wax printed reference lines. The average accuracy along the X- and Y-axis was 0.12 and 0.16 mm for cutting and 0.19 and 0.17 mm for plotting, respectively. The potential of this approach was demonstrated by fabricating μPADs for instrument-free determination of cobalt in waters using distance-based readout, with excellent precision (%RSD = 5.7) and detection limit (LOD) of 2.5 ng and 0.5 mg/L (mass and concentration LODs, respectively).

Item Type: Article
Authors/Creators:Rahbar, M and Nesterenko, PN and Paull, B and Macka, M
Keywords: microfluidic paper-based analytical devices, fabrication
Journal or Publication Title: Analytical Chemistry
Publisher: Amer Chemical Soc
ISSN: 0003-2700
DOI / ID Number: 10.1021/acs.analchem.7b03796
Copyright Information:

© 2017 American Chemical Society

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