Open Access Repository

Longitudinal associations of serum 25-hydroxyvitamin-D, physical activity, and knee pain and dysfunction with muscle loss in community-dwelling older adults

Balogun, SA ORCID: 0000-0001-6415-5536, Aitken, D ORCID: 0000-0001-5685-7634, Winzenberg, T ORCID: 0000-0002-4112-3491, Wills, K ORCID: 0000-0003-3897-2908, Scott, D, Callisaya, M ORCID: 0000-0003-2122-1622 and Jones, G ORCID: 0000-0002-9814-0006 2017 , 'Longitudinal associations of serum 25-hydroxyvitamin-D, physical activity, and knee pain and dysfunction with muscle loss in community-dwelling older adults' , Journals of Gerontology Series A: Biological Sciences and Medical Sciences, vol. 73, no. 4 , pp. 526-531 , doi: 10.1093/gerona/glx157.

Full text not available from this repository.

Abstract

Aim: To describe the associations of between-person and within-person variability in serum 25-hydroxyvitamin D (25(OH)D), physical activity (PA) and knee pain and dysfunction with muscle mass, strength and muscle quality over 10 years in community-dwelling older adults.Method: Participants (n=1033; 51% women; mean age 63±7.4 years) were measured at baseline, 2.5, 5, and 10 years. Lower-limb lean mass (LLM) was assessed using DXA, lower-limb muscle strength (LMS) using a dynamometer; and lower-limb muscle quality (LMQ) calculated as LMS/LLM. Knee pain and dysfunction were assessed using the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) index. PA was measured using pedometers. Linear mixed effect regression models, with adjustment for confounders, were used to estimate the association of within-person and between-person variability in PA, 25(OH)D and WOMAC score with muscle mass, strength and muscle quality.Results: Both between-person and within-person increases in PA were associated with LLM, LMS and LMQ (all PPPConclusions: Variability in 25(OH)D, pain and dysfunction within an individual over time relate to muscle changes in that individual. Increasing one's own physical activity level further increases muscle mass, strength and quality supporting the clinical recommendation of promoting PA to reduce age-related muscle loss.

Item Type: Article
Authors/Creators:Balogun, SA and Aitken, D and Winzenberg, T and Wills, K and Scott, D and Callisaya, M and Jones, G
Keywords: body composition, pain, physical activity, vitamin D
Journal or Publication Title: Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Publisher: Gerontological Society Amer
ISSN: 1079-5006
DOI / ID Number: 10.1093/gerona/glx157
Copyright Information:

Copyright 2017 The Author

Related URLs:
Item Statistics: View statistics for this item

Actions (login required)

Item Control Page Item Control Page
TOP