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Divergent respiratory and cardiovascular responses to hypoxia in bar-headed geese and Andean birds

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Lague, SL, Chua, B, Alza, L, Scott, GR, Frappell, PB, Zhong, Y, Farrell, AP, McCracken, KG, Wang, Y and Milsom, WK 2017 , 'Divergent respiratory and cardiovascular responses to hypoxia in bar-headed geese and Andean birds' , Journal of Experimental Biology, vol. 220, no. 22 , pp. 4186-4194 , doi: 10.1242/jeb.168799.

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Abstract

Many high-altitude vertebrates have evolved increased capacities in their oxygen transport cascade (ventilation, pulmonary diffusion, circulation and tissue diffusion), enhancing oxygen transfer from the atmosphere to mitochondria. However, the extent of interspecies variation in the control processes that dictate hypoxia responses remains largely unknown. We compared the metabolic, cardiovascular and respiratory responses to progressive decreases in inspired oxygen levels of bar-headed geese (Anser indicus), birds that biannually migrate across the Himalayan mountains, with those of Andean geese (Chloephaga melanoptera) and crested ducks (Lophonetta specularioides), lifelong residents of the high Andes. We show that Andean geese and crested ducks have evolved fundamentally different mechanisms for maintaining oxygen supply during low oxygen (hypoxia) from those of bar-headed geese. Bar-headed geese respond to hypoxia with robust increases in ventilation and heart rate, whereas Andean species increase lung oxygen extraction and cardiac stroke volume. We propose that transient high-altitude performance has favoured the evolution of robust convective oxygen transport recruitment in hypoxia, whereas life-long high-altitude residency has favoured the evolution of structural enhancements to the lungs and heart that increase lung diffusion and stroke volume.

Item Type: Article
Authors/Creators:Lague, SL and Chua, B and Alza, L and Scott, GR and Frappell, PB and Zhong, Y and Farrell, AP and McCracken, KG and Wang, Y and Milsom, WK
Keywords: altitude, ventilation, cardiac output, metabolism, goose, duck
Journal or Publication Title: Journal of Experimental Biology
Publisher: Company Of Biologists Ltd
ISSN: 0022-0949
DOI / ID Number: 10.1242/jeb.168799
Copyright Information:

Copyright 2017. Published by The Company of Biologists Ltd. Licensed under Creative Commons Attribution 3.0 Unported (CC BY 3.0) https://creativecommons.org/licenses/by/3.0/

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