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Abstract

There is increasing evidence that even mild gestational iodine deficiency (GID) results inadverse neurocognitive impacts on offspring. It’s unclear, however, if these persist long-term andwhether they can be ameliorated by iodine sufficiency in childhood. We followed a unique cohort(Gestational Iodine Cohort, n = 266) where gestation occurred during a period of mild populationiodine deficiency, with children subsequently growing-up in an iodine replete environment.We investigated whether associations between mild GID and reductions in literacy outcomes,observed at age 9-years, persisted into adolescence. Comparisons were made between offspringof mothers with gestational urinary iodine concentrations (UICs) 150 g/L and p = 0.001)) to Year 9 (5.6%, -31.6 (-57.0 to -6.2, p = 0.015)) compared to children whose mothers hadUICs 150 g/L. Associations remained after adjustment for biological factors, socioeconomic statusand adolescent UIC. Results support the hypothesis that mild GID may impact working memory andauditory processing speed. The findings have important public health implications for managementof iodine nutrition in pregnancy.

Item Type:	Article
Authors/Creators:	Hynes, KL and Otahal, P and Burgess, JR and Oddy, WH and Hay, I
Keywords:	iodine nutrition, mild iodine deficiency, gestation, childhood, adolescence, educational outcomes, literacy, working memory, auditory processing speed
Journal or Publication Title:	Nutrients
Publisher:	M D P I AG
ISSN:	2072-6643
DOI / ID Number:	10.3390/nu9121354
Copyright Information:	© 2017 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Related URLs:	Google Scholar: Hynes, KL UTAS Profile: Hynes, KL Google Scholar: Otahal, P UTAS Profile: Otahal, P Google Scholar: Oddy, WH UTAS Profile: Hay, I
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