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Association between human herpesvirus & human endogenous retrovirus and MS onset & progression

Tao, C ORCID: 0000-0002-5107-657X, Simpson Jr, S ORCID: 0000-0001-6521-3056, Taylor, BV and van der Mei, I ORCID: 0000-0001-9009-7472 2017 , 'Association between human herpesvirus & human endogenous retrovirus and MS onset & progression' , Journal of the Neurological Sciences, vol. 372 , pp. 239-249 , doi: 10.1016/j.jns.2016.11.060.

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Abstract

This review discusses the role of Epstein-Barr virus (EBV), human herpesvirus 6 (HHV6) and human endogenous retroviruses (HERVs) in the onset and progression of multiple sclerosis (MS). Although EBV has been established as one of the causal factors in MS onset, its role in MS progression is still uncertain. Moreover, interactions between EBV and other risk factor on MS development still need more investment. With less consistent evidence than EBV, HHV6 has also been implicated in the pathogenesis of MS; moreover, it showed a closer connection with the disease activity. Recent studies found that HERVs were associated with the development and progression of MS. Some antiviral treatments have shown promise for clinical interventions in the future. Future studies are yet needed to fully clarify the role of these agents in MS onset and disease course and the modes by which they realise these effects.

Item Type: Article
Authors/Creators:Tao, C and Simpson Jr, S and Taylor, BV and van der Mei, I
Keywords: Epstein-Barr virus, human endogenous retroviruses, human herpesvirus 6, multiple sclerosis, onset, progression
Journal or Publication Title: Journal of the Neurological Sciences
Publisher: Elsevier Science Bv
ISSN: 0022-510X
DOI / ID Number: 10.1016/j.jns.2016.11.060
Copyright Information:

© 2016 Elsevier B.V. All rights reserved.

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