Open Access Repository

Maternal smoking during pregnancy and offspring overweight: is there a dose-response relationship? An individual patient data meta-analysis

Albers, L, Sobotzki, C, Kuss, O, Ajslev, T, Batista, RFL, Bettiol, H, Brabin, B, Buka, SL, Cardoso, VC, Clifton, VL, Devereux, G, Gilman, SE, Grzeskowiak, LE, Heinrich, J, Hummel, S, Jacobsen, GW, Jones, G ORCID: 0000-0002-9814-0006, Koshy, G, Morgen, CS, Oken, E, Paus, T, Pausova, Z, Rifas-Shiman, SL, Sharma, AJ, da Silva, AAM, Sorensen, TIA, Thiering, E, Turner, S, Vik, T and von Kries, R 2018 , 'Maternal smoking during pregnancy and offspring overweight: is there a dose-response relationship? An individual patient data meta-analysis' , International Journal of Obesity , pp. 1-16 , doi: 10.1038/s41366-018-0050-0.

Full text not available from this repository.

Abstract

Background/Objectives: A number of meta-analyses suggest an association between any maternal smoking in pregnancy and offspring overweight obesity. Whether there is a dose-response relationship across number of cigarettes and whether this differs by sex remains unclear.Subject/Methods: Studies reporting number of cigarettes smoked during pregnancy and offspring BMI published up to May 2015 were searched. An individual patient data meta-analysis of association between the number of cigarettes smoked during pregnancy and offspring overweight (defined according to the International Obesity Task Force reference) was computed using a generalized additive mixed model with non-linear effects and adjustment for confounders (maternal weight status, breastfeeding, and maternal education) and stratification for sex.Results: Of 26 identified studies, 16 authors provided data on a total of 238,340 mother-child-pairs. A linear positive association was observed between the number of cigarettes smoked and offspring overweight for up to 15 cigarettes per day with an OR increase per cigarette of 1.03, 95% CI = [1.02-1.03]. The OR flattened with higher cigarette use. Associations were similar in males and females. Sensitivity analyses supported these results.Conclusions: A linear dose-response relationship of maternal smoking was observed in the range of 1-15 cigarettes per day equally in boys and girls with no further risk increase for doses above 15 cigarettes.

Item Type: Article
Authors/Creators:Albers, L and Sobotzki, C and Kuss, O and Ajslev, T and Batista, RFL and Bettiol, H and Brabin, B and Buka, SL and Cardoso, VC and Clifton, VL and Devereux, G and Gilman, SE and Grzeskowiak, LE and Heinrich, J and Hummel, S and Jacobsen, GW and Jones, G and Koshy, G and Morgen, CS and Oken, E and Paus, T and Pausova, Z and Rifas-Shiman, SL and Sharma, AJ and da Silva, AAM and Sorensen, TIA and Thiering, E and Turner, S and Vik, T and von Kries, R
Journal or Publication Title: International Journal of Obesity
Publisher: Nature Publishing Group
ISSN: 0307-0565
DOI / ID Number: 10.1038/s41366-018-0050-0
Copyright Information:

Copyright 2018 Macmillan Publishers Limited, part of Springer Nature

Related URLs:
Item Statistics: View statistics for this item

Actions (login required)

Item Control Page Item Control Page
TOP