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The pro-inflammatory effects of particulate matter on epithelial cells are associated with elemental composition

Shao, J ORCID: 0000-0003-0794-2810, Wheeler, AJ ORCID: 0000-0001-9288-8163, Chen, L ORCID: 0000-0003-1897-9264, Strandberg, B, Hinwood, A, Johnston, FH ORCID: 0000-0002-5150-8678 and Zosky, GR ORCID: 0000-0001-9039-0302 2018 , 'The pro-inflammatory effects of particulate matter on epithelial cells are associated with elemental composition' , Chemosphere, vol. 202 , pp. 530-537 , doi: 10.1016/j.chemosphere.2018.03.052.

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Abstract

Background: Adverse health effects of particulate matter (PM) vary with chemical composition; however, evidence regarding which elements are the most detrimental is limited. The roof space area provides an open and stable environment for outdoor PM to settle and deposit. Therefore, this study used roof space PM samples as a proxy of residential cumulative exposure to outdoor air pollution to investigate their pro-inflammatory effects on human lung cells and the contribution of the endotoxin and chemical content.Methods: Roof space PM samples of 36 different homes were collected and analysed using standardised techniques. We evaluated cytotoxicity and cytokine production of BEAS-2B cells after PM exposure using MTS and ELISA, respectively. Principle component analysis (PCA) and linear regression analyses were employed to assess the associations between cytokine production and the PM components.Results: PM caused significant time- and dose-dependent increases in cellular cytokine production (p Conclusions: Our study provides novel insight into the positive associations between pro-inflammatory effects of roof space PM samples with Fe, Al and Mn levels.

Item Type: Article
Authors/Creators:Shao, J and Wheeler, AJ and Chen, L and Strandberg, B and Hinwood, A and Johnston, FH and Zosky, GR
Keywords: air pollution. element, inflammation, particulate matter
Journal or Publication Title: Chemosphere
Publisher: Pergamon-Elsevier Science Ltd
ISSN: 0045-6535
DOI / ID Number: 10.1016/j.chemosphere.2018.03.052
Copyright Information:

Copyright 2018 Elsevier Ltd.

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