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Abstract

Purpose: The study aimed to determine the effects of exertional-heat stress on gastrointestinal integrity, symptoms, systemic endotoxin and inflammatory responses; and assess the relationship between changes in body temperature and gastrointestinal perturbations. Methods: Ten endurance runners completed 2 h running at 60% V02max in hot (HOT: 35 °C) and temperate (TEMP: 22 °C)­ambient conditions. Rectal temperature (Tre) and gastrointestinal symptoms were recorded every 10 min during exercise. Blood samples were collected pre- and post-exercise, and during recovery to determine plasma intestinal fatty acid binding protein (I-FABP), cortisol, bacterial endotoxin and cytokine profile. Calprotectin was determined from pre- and post-exercise faecal samples. Urinary lactulose:L-rhamnose ratio was used to measure intestinal permeability. Results: Compared with TEMP, HOT significantly increased Tre (1.4 ± 0.5 vs 2.4 ± 0.8 °C, p Conclusions: Exertional-heat stress induces a thermoregulatory strain that subsequently injures the intestinal epithelium, reduces endotoxin clearance capacity, promotes greater cytokinaemia, and development of gastrointestinal symptoms.

Item Type:	Article
Authors/Creators:	Snipe, RMJ and Khoo, A and Kitic, CM and Gibson, PR and Costa, RJS
Keywords:	Euhydration · Running · Permeability · I-FABP · Calprotectin · Inflammation
Journal or Publication Title:	European Journal of Applied Physiology
Publisher:	Springer-Verlag
ISSN:	1439-6319
DOI / ID Number:	10.1007/s00421-017-3781-z
Copyright Information:	Copyright 2017 Springer-Verlag GmbH Germany, part of Springer Nature
Related URLs:	Google Scholar: Kitic, CM UTAS Profile: Kitic, CM
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