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Abstract

Background: Cardiovascular disease is the leading cause of morbidity and mortality in patients receiving hemodialysis. Systemic metabolic perturbation is one of the hallmark abnormalities in patients at high cardiovascular risk. We sought to determine the relationship between circulating ketone body and clinical outcomes in patients with prevalent hemodialysis.Methods and Results: We retrospectively assessed the relationship between serum β-hydroxybutyrate (βOHB), the most abundant ketone body in the circulation, and prognosis in 405 stable hemodialysis patients. During a mean follow-up of 3.2±0.9 years, there were 54 major adverse cardiovascular events (defined as cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, and hospitalization attributed to heart failure) and 67 all-cause deaths. Major adverse cardiovascular events rates increased from 11.1 per 1000 person-years in the lowest βOHB quintile (409 μmol/L). After adjusting for demographic characteristics, coronary artery disease, and atrial fibrillation, the highest βOHB quintile was associated with increased risk of major adverse cardiovascular events compared with the lowest quintile (hazard ratio, 10.2; 95% confidence interval [3.35-44.0]; PPConclusions: Increased serum βOHB levels were independently associated with cardiovascular events and all-cause death in patients receiving hemodialysis. These results highlight the need for future studies to understand the mechanisms underlying these observations.

Item Type:	Article
Authors/Creators:	Obokata, M and Negishi, K and Sunaga, H and Ishida, H and Ito, K and Ogawa, T and Iso, T and Ando, Y and Kurabayashi, M
Keywords:	hemodialysis, ketone body, metabolism, prognostic factor, β‐hydroxybutyrate
Journal or Publication Title:	Journal of the American Heart Association
Publisher:	Wiley-Blackwell Publishing, Inc.
ISSN:	2047-9980
DOI / ID Number:	10.1161/JAHA.117.006885
Copyright Information:	Copyright 2017 The Authors. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) https://creativecommons.org/licenses/by-nc-nd/4.0/
Related URLs:	Google Scholar: Negishi, K UTAS Profile: Negishi, K
Item Statistics:	View statistics for this item

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