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Abstract

Exercise has been demonstrated to have considerable effects upon haemostasis, with activation dependent upon the duration and intensity of the exercise bout. In addition, markers of coagulation and fibrinolysis have been shown to possess circadian rhythms, peaking within the morning (0600-1200 h). Therefore, the time of day in which exercise is performed may influence the activation of the coagulation and fibrinolytic systems. This study aimed to examine coagulation and fibrinolytic responses to short-duration high-intensity exercise when completed at different times of the day. Fifteen male cyclists (VO2max: 60.3 ± 8.1 ml kg-1 min-1) completed a 4-km cycling time trial (TT) on five separate occasions at 0830, 1130, 1430, 1730 and 2030. Venous blood samples were obtained pre- and immediately post-exercise, and analysed for tissue factor (TF), tissue factor pathway inhibitor (TFPI), thrombin-anti-thrombin complexes (TAT) and D-Dimer. Exercise significantly increased plasma concentrations of TF (p  .05); however, percentage VO2max was greater at 1730 when compared to 2030 (p = .04). Due to a time-of-day effect present within TF, peaking at 0830, caution should be applied when prescribing short-duration high-intensity exercise bout within the morning in populations predisposed to hypercoagulability.

Item Type:	Article
Authors/Creators:	Zadow, EK and Kitic, CM and Wu, SSX and Fell, JW and Adams, MJ
Keywords:	Thrombin, anti-thrombin III, D-dimer, circadian rhythm, cycling, KICKR
Journal or Publication Title:	European journal of sport science
Publisher:	Routledge/Taylor & Francis
ISSN:	1536-7290
DOI / ID Number:	https://doi.org/10.1080/17461391.2017.1420237
Copyright Information:	Copyright 2018 European College of Sport Science
Related URLs:	UTAS Profile: Zadow, EK Google Scholar: Kitic, CM UTAS Profile: Kitic, CM Google Scholar: Fell, JW UTAS Profile: Fell, JW
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