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Serum levels of resistin and interleukin-17 are associated with increased cartilage defects and bone marrow lesions in patients with knee osteoarthritis

Wang, K, Xu, J, Cai, J, Zheng, S, Yang, X and Ding, C ORCID: 0000-0002-9479-730X 2017 , 'Serum levels of resistin and interleukin-17 are associated with increased cartilage defects and bone marrow lesions in patients with knee osteoarthritis' , Modern Rheumatology, vol. 27, no. 2 , pp. 339-344 , doi: 10.1080/14397595.2016.1205777.

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Abstract

Objectives: To investigate cross-sectional associations between serum levels of resistin and interleukin-17 (IL-17) and cartilage defects and bone marrow lesions (BMLs) in patients with knee symptomatic osteoarthritis (OA).Methods: One hundred and ninety-four consecutively-selected patients with knee symptomatic OA (mean 55.4 years, range 34-74, 87% females) were included in Anhui Osteoarthritis (AHOA) Study. Knee cartilage defects and BMLs were determined at different sites using T2-weighted fat-suppressed fast spin echo MRI. Serum resistin, IL-17, and high-sensitivity C-reactive protein (hs-CRP) levels were measured using ELISA.Results: In multivariable analyses, serum resistin was positively associated with cartilage defects at lateral femoral, lateral tibial, and medial tibial (all p p 2.45 pg/ml), IL-17 was positively and significantly associated with cartilage defect score at nearly all sites (ORs: 1.33-1.44, all p p Conclusions: Serum levels of resistin were positively and independently associated with cartilage defects and BMLs in patients with knee OA. Serum IL-17 was significantly associated with cartilage defects and BMLs in patients with an increased inflammatory status. These suggest that metabolic and inflammatory mechanisms may have a role to play in knee OA.

Item Type: Article
Authors/Creators:Wang, K and Xu, J and Cai, J and Zheng, S and Yang, X and Ding, C
Keywords: bone, cartilage, Interleukin-17, osteoarthritis, resistin
Journal or Publication Title: Modern Rheumatology
Publisher: Taylor & Francis
ISSN: 1439-7595
DOI / ID Number: 10.1080/14397595.2016.1205777
Copyright Information:

Copyright 2016 Japan College of Rheumatology

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