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High resolution propagation-based imaging system for in vivo dynamic computed tomography of lungs in small animals

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Preissner, M, Murrie, RP, Pinar, I, Werdiger, F, Carnibella, RP, Zosky, GR ORCID: 0000-0001-9039-0302 and Dubsky, S 2018 , 'High resolution propagation-based imaging system for in vivo dynamic computed tomography of lungs in small animals' , Physics in medicine and biology, vol. 63, no. 8 , pp. 1-8 , doi: 10.1088/1361-6560/aab8d2.

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Abstract

We have developed an x-ray imaging system for I>in vivo four-dimensional computed tomography(4DCT) of small animals for pre-clinical lung investigations. Our customized laboratory facility iscapable of high resolution in vivo imaging at high frame rates. Characterization using phantomsdemonstrate a spatial resolution of slightly below 50 μm at imaging rates of 30 Hz, and the abilityto quantify material density differences of at least 3%. We benchmark our system against existingsmall animal pre-clinical CT scanners using a quality factor that combines spatial resolution, imagenoise, dose and scan time. In vivo. 4DCT images obtained on our system demonstrate resolution ofimportant features such as blood vessels and small airways, of which the smallest discernible weremeasured as 55–60 μm in cross section. Quantitative analysis of the images demonstrate regionaldifferences in ventilation between injured and healthy lungs.

Item Type: Article
Authors/Creators:Preissner, M and Murrie, RP and Pinar, I and Werdiger, F and Carnibella, RP and Zosky, GR and Dubsky, S
Keywords: 4DCT, in vivo, x-ray imaging, functional imaging, biological imaging, tomography
Journal or Publication Title: Physics in medicine and biology
Publisher: IOP Publishing
ISSN: 0031-9155
DOI / ID Number: 10.1088/1361-6560/aab8d2
Copyright Information:

© 2018 Institute of Physics and Engineering in Medicine. Licensed under Creative Commons Attribution 3.0 Unported (CC BY 3.0) https://creativecommons.org/licenses/by/3.0/

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