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DHA mediates the protective effect of fish consumption on new episodes of depression among women
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Abstract
In a longitudinal cohort study of young Australian adults, we reported that for women higher baseline levels of fish consumption were associated with reduced incidence of new depressive episodes during the 5-year follow-up. Fish are high in both n-3 fatty acids and tyrosine. In this study, we seek to determine whether n-3 fatty acids or tyrosine explain the observed association. During 2004-2006, a FFQ (nine fish items) was used to estimate weekly fish consumption among 546 women aged 26-36 years. A fasting blood sample was taken and high-throughput NMR spectroscopy was used to measure 233 metabolites, including serum n-3 fatty acids and tyrosine. During 2009-2011, new episodes of depression since baseline were identified using the lifetime version of the Composite International Diagnostic Interview. Relative risks were calculated using log-binomial regression and indirect effects estimated using the STATA binary_mediation command. Potential mediators were added to separate models, and mediation was quantified as the proportion of the total effect due to the mediator. The n-3 DHA mediated 25·3 % of the association between fish consumption and depression when fish consumption was analysed as a continuous variable and 16·6 % when dichotomised (reference group: n-3 fatty acids and tyrosine might be beneficial for women's mental health.
Item Type: | Article |
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Authors/Creators: | Reeves, JL and Otahal, P and Magnussen, CG and Dwyer, T and Kangas, AJ and Soininen, P and Ala-Korpela, M and Venn, AJ and Smith, KJ |
Keywords: | fish, depression, omega-3, young adults, mediation, tyrosine |
Journal or Publication Title: | The British Journal of Nutrition |
Publisher: | C A B I Publishing |
ISSN: | 0007-1145 |
DOI / ID Number: | 10.1017/S0007114517002768 |
Copyright Information: | © The Authors 2017 and Cambridge University Press |
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Item Statistics: | View statistics for this item |
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