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DHA mediates the protective effect of fish consumption on new episodes of depression among women


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Reeves, JL, Otahal, P ORCID: 0000-0003-4042-1769, Magnussen, CG ORCID: 0000-0002-6238-5730, Dwyer, T, Kangas, AJ, Soininen, P, Ala-Korpela, M, Venn, AJ ORCID: 0000-0001-7090-1398 and Smith, KJ ORCID: 0000-0003-2793-3460 2017 , 'DHA mediates the protective effect of fish consumption on new episodes of depression among women' , The British Journal of Nutrition, vol. 118 , 743–749 , doi: 10.1017/S0007114517002768.

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In a longitudinal cohort study of young Australian adults, we reported that for women higher baseline levels of fish consumption were associated with reduced incidence of new depressive episodes during the 5-year follow-up. Fish are high in both n-3 fatty acids and tyrosine. In this study, we seek to determine whether n-3 fatty acids or tyrosine explain the observed association. During 2004-2006, a FFQ (nine fish items) was used to estimate weekly fish consumption among 546 women aged 26-36 years. A fasting blood sample was taken and high-throughput NMR spectroscopy was used to measure 233 metabolites, including serum n-3 fatty acids and tyrosine. During 2009-2011, new episodes of depression since baseline were identified using the lifetime version of the Composite International Diagnostic Interview. Relative risks were calculated using log-binomial regression and indirect effects estimated using the STATA binary_mediation command. Potential mediators were added to separate models, and mediation was quantified as the proportion of the total effect due to the mediator. The n-3 DHA mediated 25·3 % of the association between fish consumption and depression when fish consumption was analysed as a continuous variable and 16·6 % when dichotomised (reference group: n-3 fatty acids and tyrosine might be beneficial for women's mental health.

Item Type: Article
Authors/Creators:Reeves, JL and Otahal, P and Magnussen, CG and Dwyer, T and Kangas, AJ and Soininen, P and Ala-Korpela, M and Venn, AJ and Smith, KJ
Keywords: fish, depression, omega-3, young adults, mediation, tyrosine
Journal or Publication Title: The British Journal of Nutrition
Publisher: C A B I Publishing
ISSN: 0007-1145
DOI / ID Number: 10.1017/S0007114517002768
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© The Authors 2017 and Cambridge University Press

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