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Abstract

In a longitudinal cohort study of young Australian adults, we reported that for women higher baseline levels of fish consumption were associated with reduced incidence of new depressive episodes during the 5-year follow-up. Fish are high in both n-3 fatty acids and tyrosine. In this study, we seek to determine whether n-3 fatty acids or tyrosine explain the observed association. During 2004-2006, a FFQ (nine fish items) was used to estimate weekly fish consumption among 546 women aged 26-36 years. A fasting blood sample was taken and high-throughput NMR spectroscopy was used to measure 233 metabolites, including serum n-3 fatty acids and tyrosine. During 2009-2011, new episodes of depression since baseline were identified using the lifetime version of the Composite International Diagnostic Interview. Relative risks were calculated using log-binomial regression and indirect effects estimated using the STATA binary_mediation command. Potential mediators were added to separate models, and mediation was quantified as the proportion of the total effect due to the mediator. The n-3 DHA mediated 25·3 % of the association between fish consumption and depression when fish consumption was analysed as a continuous variable and 16·6 % when dichotomised (reference group: n-3 fatty acids and tyrosine might be beneficial for women's mental health.

Item Type:	Article
Authors/Creators:	Reeves, JL and Otahal, P and Magnussen, CG and Dwyer, T and Kangas, AJ and Soininen, P and Ala-Korpela, M and Venn, AJ and Smith, KJ
Keywords:	fish, depression, omega-3, young adults, mediation, tyrosine
Journal or Publication Title:	The British Journal of Nutrition
Publisher:	C A B I Publishing
ISSN:	0007-1145
DOI / ID Number:	10.1017/S0007114517002768
Copyright Information:	© The Authors 2017 and Cambridge University Press
Related URLs:	Google Scholar: Otahal, P UTAS Profile: Otahal, P Google Scholar: Magnussen, CG UTAS Profile: Magnussen, CG Google Scholar: Venn, AJ UTAS Profile: Venn, AJ Google Scholar: Smith, KJ UTAS Profile: Smith, KJ
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