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Abstract

B cells are known to play a dominant pathogenic role in autoimmune conditions such as systemic lupus erythematosus (SLE) and rheumatoid arthritis. In recent times, the chemokine receptor CCR6 and its cognate ligand CCL20 have been shown to play a role in the fundamental kinetics of germinal centres and B cell responses. As CCR6 is found on B cells and is upregulated after activation, we investigated the expression of CCR6 on naive, pre-germinal centre (GC), GC/plasma cell and memory B cells in peripheral B cells of SLE patients and healthy controls using flow cytometry. Pre-germinal centre B cells are found in lower proportions and the expression of CCR6 is increased on B cells of SLE patients, suggesting a role for the chemokine pair in the pathogenesis of the disease. Further studies are needed to explore these preliminary results.

Item Type:	Article
Authors/Creators:	Lee, AYS and Bannan, JL and Adams, MJ and Korner, H
Keywords:	B cells, CCR6, Chemokines, SLE
Journal or Publication Title:	Clinical Rheumatology
Publisher:	Springer-Verlag
ISSN:	0770-3198
DOI / ID Number:	https://doi.org/10.1007/s10067-017-3652-3
Copyright Information:	© International League of Associations for Rheumatology (ILAR) 2017
Related URLs:	Google Scholar: Korner, H UTAS Profile: Korner, H
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