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Stability of Cefazolin in Polyisoprene Elastomeric Infusion Devices

Patel, RP ORCID: 0000-0001-9344-1013, Jacob, J, Sedeeq, M, Ming, LC ORCID: 0000-0002-6971-1383, Wanandy, T ORCID: 0000-0003-4703-0488, Zaidi, STR ORCID: 0000-0002-2031-1055 and Peterson, GM ORCID: 0000-0002-6764-3882 2018 , 'Stability of Cefazolin in Polyisoprene Elastomeric Infusion Devices' , Clinical therapeutics, vol. 40 , doi: 10.1016/j.clinthera.2018.02.009.

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Abstract

PURPOSE:The aim was to investigate the stability of cefazolin in elastomeric infusion devices.METHODS:Elastomeric devices (Infusor LV) that contain cefazolin (3 g/240 mL and 6 g/240 mL) were prepared and stored at 4°C for 72 hours and then at 35°C for 12 hours, followed by 25°C for 12 hours. An aliquot was withdrawn at predefined time points and analyzed for the concentration of cefazolin. Samples were also assessed for changes in pH, solution color, and particle content.FINDINGS:Cefazolin retained acceptable chemical and physical stability over the studied storage period and conditions.IMPLICATIONS:These findings will allow the administration of cefazolin by the Infusor LV elastomeric device in the outpatient and remote settings.

Item Type: Article
Authors/Creators:Patel, RP and Jacob, J and Sedeeq, M and Ming, LC and Wanandy, T and Zaidi, STR and Peterson, GM
Keywords: Cefazolin stability elastomeric infusion
Journal or Publication Title: Clinical therapeutics
Publisher: Excerpta Medica Inc
ISSN: 0149-2918
DOI / ID Number: 10.1016/j.clinthera.2018.02.009
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Copyright 2018 Elsevier HS Journals,Inc. All rights reserved.

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