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Abstract

Objective: Secretory phospholipase A2 (sPLA2) enzyme activity is a potential inflammatory biomarker for cardiovascular disease. We examined the tracking, or persistence, of sPLA2 enzyme activity levels from childhood to adulthood, and identify potentially modifiable factors affecting tracking.Method: Prospective cohort of 1735 children (45% females) who had serum sPLA2 enzyme activity levels and other cardiovascular disease risk factors measured in 1980 that were followed-up in 2001.Results: sPLA2 activity tracked from childhood to adulthood for males (r=0.39) and females (r=0.45). Those who decreased body mass index relative to their peers were more likely to resolve elevated childhood sPLA2 levels than have persistent elevated sPLA2 levels in childhood and adulthood. Those who consumed less fruit, and gained more body mass index relative to their peers, began smoking or were a persistent smoker between childhood and adulthood were more likely to develop incident elevated sPLA2 levels than those with persistent not elevated sPLA2 levels.Conclusions: Childhood sPLA2 enzyme activity levels associate with adult sPLA2 levels 21 years later. Healthful changes in modifiable risk factors that occur between childhood and adulthood might prevent children from developing elevated sPLA2 levels in adulthood.

Item Type:	Article
Authors/Creators:	Chung, O and Juonala, M and Mallat, Z and Hutri-Kahonen, N and Viikari, JSA and Raitakari, OT and Magnussen, CG
Keywords:	atherosclerosis, cohort study, inflammation, prevention
Journal or Publication Title:	Jornal de Pediatria
Publisher:	Sociedade Brasileira de Pediatria
ISSN:	0021-7557
DOI / ID Number:	10.1016/j.jped.2018.01.002
Copyright Information:	© 2018 Published by Elsevier Editora Ltda. on behalf of Sociedade Brasileira de Pediatria. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) http://creativecommons.org/licenses/by-nc-nd/4.0/
Related URLs:	Google Scholar: Magnussen, CG UTAS Profile: Magnussen, CG
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