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Vitamin D and parathyroid hormone are associated with gait instability and poor balance performance in mid-age to older aged women

Bird, ML ORCID: 0000-0001-9642-7196, El Haber, N, Batchelor, F, Hill, K and Wark, JD 2018 , 'Vitamin D and parathyroid hormone are associated with gait instability and poor balance performance in mid-age to older aged women' , Gait and Posture, vol. 59 , pp. 71-75 , doi: 10.1016/j.gaitpost.2017.09.036.

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Context:Vitamin D status and parathyroid hormone (PTH) levels influence the risk of accidental falls in older people, but the mechanisms underlying this effect remain unclear.Objective:Investigate the relationship between circulating PTH and 25 hydroxyvitamin D (25-OHD) levels and clinical tests of gait stability and balance as physical fall risk factors. We hypothesized that high levels of PTH and low 25-OHD levels would be significantly associated with gait stability and decreased balance performance.Design:Observational cohort study.Setting:Australian community.Participants:119 healthy, ambulatory female twin adults aged 47–80 years residing in Victoria, Australia.Outcome measures:Serum PTH and 25-OHD levels with clinical tests of gait stability [double support duration (DSD)] and dynamic balance (Step Test). Associations were investigated by regression analysis and by comparing groups divided by tertiles of PTH (4.9 pmol/L) and 25-OHD (75 nmol/L) using analysis of variance.Results:Serum PTH was associated positively with DSD, with an increase of 10.6–15.7% when the mid and highest PTH tertiles were compared to the lowest tertile (p Conclusion:These findings reveal an important new relationship between parathyroid hormone and gait stability parameters and add to understanding of the role of 25-OHD in motor control of gait and dynamic balance in community-dwelling women across a wide age span.

Item Type: Article
Authors/Creators:Bird, ML and El Haber, N and Batchelor, F and Hill, K and Wark, JD
Keywords: accidental falls, motor control, posture
Journal or Publication Title: Gait and Posture
Publisher: Elsevier Sci Ireland Ltd
ISSN: 0966-6362
DOI / ID Number: 10.1016/j.gaitpost.2017.09.036
Copyright Information:

Copyright 2017 Elsevier B.V.

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