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Experimental infection by Yersinia ruckeri O1 biotype 2 induces brain lesions and neurological signs in rainbow trout (Oncorhynchus mykiss)

Strom, HK, Ohtani, M, Nowak, B ORCID: 0000-0002-0347-643X, Boutrup, TS, Jones, B, Raida, MK and Bojesen, AM 2018 , 'Experimental infection by Yersinia ruckeri O1 biotype 2 induces brain lesions and neurological signs in rainbow trout (Oncorhynchus mykiss)' , Journal of Fish Diseases, vol. 41, no. 3 , pp. 529-537 , doi: 10.1111/jfd.12754.

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Abstract

Pathological manifestations in rainbow trout (Oncorhynchus mykiss) following experimental waterborne infection with Yersinia ruckeri serotype O1 biotype 2 (strain 07111224) were investigated. Rainbow trout were exposed to 8 × 107 CFU/ml of Y. ruckeri by bath for 6 hr, and mortality was then monitored for 22 days post-infection (dpi). Organs were sampled at 3 dpi and also from moribund fish showing signs of severe systemic infection such as bleeding, exophthalmia or erratic swimming behaviour. Y. ruckeri was observed in the meninges and diencephalon of the brain, and lamina propria of olfactory organ at 3 dpi. At 12 dpi, Y. ruckeri had spread throughout the brain including cranial connective tissues and ventricles and the infection was associated with haemorrhages and an infiltration with leucocytes. Y. ruckeri infection and associated with leucocyte infiltration were observed at 13 dpi. In conclusion, Y. ruckeri strain 07111224 causes encephalitis in the acute phase of infection, which could explain why Y. ruckeri-affected fish show exophthalmia and erratic swimming known as signs of ERM.

Item Type: Article
Authors/Creators:Strom, HK and Ohtani, M and Nowak, B and Boutrup, TS and Jones, B and Raida, MK and Bojesen, AM
Keywords: rainbow trout, ERM, pathology, central nervous system, encephalitis, olfactory organ, ventriculitis, Yersinia ruckeri serotype O1 biotype 2
Journal or Publication Title: Journal of Fish Diseases
Publisher: Blackwell Publishing Ltd
ISSN: 0140-7775
DOI / ID Number: 10.1111/jfd.12754
Copyright Information:

© 2017 John Wiley & Sons Ltd

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