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Abstract

Objectives: To assess whether childhood cardiorespiratory fitness (CRF) and muscular fitness phenotypes (strength, power, endurance) predict adult glucose homeostasis measures.Design: Prospective longitudinal study.Methods: Study examining participants who had physical fitness measured in childhood (aged 7-15 years) and who attended follow-up clinics approximately 20 years later and provided a fasting blood sample which was tested for glucose and insulin. Physical fitness measurements included muscular strength (right and left grip, shoulder flexion, shoulder and leg extension), power (standing long jump distance) and endurance (number of push-ups in 30s), and CRF (1.6km run duration). In adulthood, fasting glucose and insulin levels were used to derive glucose homeostasis measures of insulin resistance (HOMA2-IR) and beta cell function (HOMA2-β).Results: A standard deviation increase in childhood CRF or muscular strength (males) was associated with fasting glucose (CRF: β=-0.06mmol/L), fasting insulin (CRF: β=-0.73mU/L; strength: β=-0.40mU/L), HOMA2-IR (CRF: β=-0.06; strength: β=-0.05) and HOMA2-β (CRF: β=-3.06%; strength: β=-2.62%) in adulthood, independent of the alternative fitness phenotype (all p0.06).Conclusions: CRF and muscular fitness in childhood were inversely associated with measures of fasting insulin, insulin resistance and beta cell function in adulthood. Childhood CRF and muscular fitness could both be potential independent targets for strategies to help reduce the development of adverse glucose homeostasis.

Item Type:	Article
Authors/Creators:	Fraser, BJ and Blizzard, L and Schmidt, MD and Juonala, M and Dwyer, T and Venn, AJ and Magnussen, CG
Keywords:	beta cell function, cohort, epidemiology, insulin resistance, muscle strength, physical fitness
Journal or Publication Title:	Journal of Science and Medicine in Sport
Publisher:	Sports Medicine Australia
ISSN:	1440-2440
DOI / ID Number:	10.1016/j.jsams.2018.02.002
Copyright Information:	Copyright 2018 Sports Medicine Australia
Related URLs:	UTAS Profile: Blizzard, L Google Scholar: Venn, AJ UTAS Profile: Venn, AJ Google Scholar: Magnussen, CG UTAS Profile: Magnussen, CG
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