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1α,25-Dihydroxyvitamin D3 up-regulates IL-34 expression in SH-SY5Y neural cells

Zhang, D, Li, M, Dong, Y, Zhang, X, Liu, X, Chen, Z, Zhu, Y, Wang, Huiming, Liu, X, Zhu, J, Shen, Y, Korner, H ORCID: 0000-0003-4610-2814, Ying, S, Fang, S and Shen, Y 2017 , '1α,25-Dihydroxyvitamin D3 up-regulates IL-34 expression in SH-SY5Y neural cells' , Innate Immunity, vol. 23, no. 7 , pp. 584-591 , doi: 10.1177/1753425917725391.

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Vitamin D supplementation is regarded as a novel approach to treat Alzheimer's disease, but the underlying mechanism remains elusive. The cytokine IL-34 provides strong neuroprotective and survival signals in brain injury and neurodegeneration and could be an immunological mediator for the vitamin D-induced protection. The aim of this study was to investigate whether human IL-34 is up-regulated in neuronal cells by the hormonally active form of vitamin D, 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3]. We found that IL-34 was detectable in a variety of cell lines and its expression was strongly induced in SH-SY5Y neural cells in a dose- and time-dependent manner by 1α,25(OH)2D3 through the vitamin D receptor (VDR). Furthermore, we identified the core promoter of IL-34 gene and a VDR binding site (CGCCCT) that was required for 1α,25(OH)2D3-induced IL-34 expression. These findings suggest that the induction of IL-34 expression by 1α,25(OH)2D3 may constitute a mechanism that explains the protective function of vitamin D in Alzheimer's disease.

Item Type: Article
Authors/Creators:Zhang, D and Li, M and Dong, Y and Zhang, X and Liu, X and Chen, Z and Zhu, Y and Wang, Huiming and Liu, X and Zhu, J and Shen, Y and Korner, H and Ying, S and Fang, S and Shen, Y
Keywords: 1α, 25-Dihydroxyvitamin D3, Alzheimer disease, IL-34, expression, neuronal cell
Journal or Publication Title: Innate Immunity
Publisher: Sage Publications Ltd.
ISSN: 1753-4259
DOI / ID Number: 10.1177/1753425917725391
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Copyright 2017 The Authors

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