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Obesity and multiple sclerosis: Prevalence, susceptibility and progression in disability

Tettey, P ORCID: 0000-0001-7461-2382 and Balogun, S ORCID: 0000-0001-6415-5536 2017 , 'Obesity and multiple sclerosis: Prevalence, susceptibility and progression in disability' , Future Neurology, vol. 12, no. 3 , pp. 149-157 , doi: 10.2217/fnl-2017-0012.

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Abstract

Recent emerging data indicate that obesity is an important risk factor for multiple sclerosis (MS) susceptibility and may be associated with MS disability progression. Marked interactions between obesity and human leukocyte antigen (HLA) genotype with regard to the risk of MS have been reported. Evidence from Mendelian randomization studies also point to a causal relationship between obesity and MS risk. In this report, we aimed to analyze the current evidence of the relationship between obesity and risk of MS and disability progression, examine data on the interaction between obesity and HLA risk genes of MS and Mendelian randomization studies and to explore the plausible biological mechanisms that may underlie this relationship.

Item Type: Article
Authors/Creators:Tettey, P and Balogun, S
Keywords: body mass index, disability progression, human leukocyte antigen, Mendelian randomization, multiple sclerosis, obesity, prevalence, susceptibility
Journal or Publication Title: Future Neurology
Publisher: Future Medicine Ltd.
ISSN: 1479-6708
DOI / ID Number: 10.2217/fnl-2017-0012
Copyright Information:

Copyright 2017 Future Medicine Ltd

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