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Abstract

Context:Patients with multiple endocrine neoplasia type 1 (MEN1) are at high risk of malignant pancreatic neuroendocrine tumors (pNETs). Structural imaging is typically used to screen for pNETs but is suboptimal for stratifying malignant potential.Objective:To determine the utility of fluorodeoxyglucose (18F) positron emission tomography/computed tomography (18F-FDG PET/CT) for predicting the malignant potential of pNETs in MEN1.Design:Retrospective observational study.Setting:Tertiary referral hospital.Patients:Forty-nine adult patients with MEN1 carrying a common MEN1 mutation who underwent 18F-FDG PET/CT for MEN1 surveillance between 1 January 2010 and 30 September 2016.Interventions:Structural and functional imaging (magnetic resonance imaging, CT, ultrasonography, and 18F-FDG PET/CT) and surgical histopathology.Main Outcome Measures:pNET size, behavior, and histopathology.

Item Type:	Article
Authors/Creators:	Kornaczewski Jackson, ER and Pointon, OP and Bohmer, R and Brugess, JR
Keywords:	FDG-PET, pancreas, neuroendocrine tumours, MEN 1
Journal or Publication Title:	Journal of Clinical Endocrinology and Metabolism
Publisher:	Oxford University Press
ISSN:	0021-972X
DOI / ID Number:	10.1210/jc.2016-3865
Copyright Information:	Copyright 2017 Endocrine Society
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