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Utility of FDG-PET imaging for risk stratification of pancreatic neuroendocrine tumors in MEN1

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Abstract
Context:Patients with multiple endocrine neoplasia type 1 (MEN1) are at high risk of malignant pancreatic neuroendocrine tumors (pNETs). Structural imaging is typically used to screen for pNETs but is suboptimal for stratifying malignant potential.Objective:To determine the utility of fluorodeoxyglucose (18F) positron emission tomography/computed tomography (18F-FDG PET/CT) for predicting the malignant potential of pNETs in MEN1.Design:Retrospective observational study.Setting:Tertiary referral hospital.Patients:Forty-nine adult patients with MEN1 carrying a common MEN1 mutation who underwent 18F-FDG PET/CT for MEN1 surveillance between 1 January 2010 and 30 September 2016.Interventions:Structural and functional imaging (magnetic resonance imaging, CT, ultrasonography, and 18F-FDG PET/CT) and surgical histopathology.Main Outcome Measures:pNET size, behavior, and histopathology.
Item Type: | Article |
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Authors/Creators: | Kornaczewski Jackson, ER and Pointon, OP and Bohmer, R and Brugess, JR |
Keywords: | FDG-PET, pancreas, neuroendocrine tumours, MEN 1 |
Journal or Publication Title: | Journal of Clinical Endocrinology and Metabolism |
Publisher: | Oxford University Press |
ISSN: | 0021-972X |
DOI / ID Number: | 10.1210/jc.2016-3865 |
Copyright Information: | Copyright 2017 Endocrine Society |
Item Statistics: | View statistics for this item |
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