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Abstract

Evolved dependence is a process through which one species becomes ‘dependent’ on another following a long evolutionary history of interaction. This happens when adaptations selected in the first species for interacting lead to fitness costs when the second species is not encountered. Evolved dependence is frequent in host–parasite interactions, where hosts may achieve a higher fitness in the presence of the parasite than in its absence. Since oncogenic manifestations are (i) ubiquitous across multicellular life, (ii) involved in parasitic-like interactions with their hosts, and (iii) have effectively driven the selection of numerous adaptations, it is possible that multicellular organisms display evolved dependence in response to oncogenic processes. We provide a comprehensive overview of the topic, including the implications for cancer prevention and treatment.

Item Type:	Article
Authors/Creators:	Thomas, F and Kareva, I and Raven, N and Hamede, R and Pujol, P and Roche, B and Ujvari, B
Keywords:	cancer, eology, evolution
Journal or Publication Title:	Trends in Ecology and Evolution
Publisher:	Elsevier Science London
ISSN:	0169-5347
DOI / ID Number:	10.1016/j.tree.2018.01.012
Copyright Information:	Copyright 2018 Elsevier Ltd.
Related URLs:	Google Scholar: Hamede, R UTAS Profile: Hamede, R
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