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Association of childhood adiposity measures with adulthood knee cartilage defects and bone marrow lesions: a 25-year cohort study

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Meng, T, Thayer, S, Venn, A ORCID: 0000-0001-7090-1398, Wu, F ORCID: 0000-0003-3753-974X, Cicuttini, F, March, L, Dwyer, T, Halliday, A, Cross, M, Laslett, LL ORCID: 0000-0002-4336-0095, Jones, G ORCID: 0000-0002-9814-0006, Ding, C ORCID: 0000-0002-9479-730X and Antony, B ORCID: 0000-0001-8704-6084 2018 , 'Association of childhood adiposity measures with adulthood knee cartilage defects and bone marrow lesions: a 25-year cohort study' , Osteoarthritis and Cartilage, no. May , pp. 1-8 , doi: 10.1016/j.joca.2018.05.008.

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Abstract

Objective: To describe the associations between childhood adiposity measures and adulthood knee cartilage defects and bone marrow lesions (BMLs) measured 25 years later.Methods: 327 participants from the Australian Schools Health and Fitness Survey (ASHFS) of 1985 (aged 7-15 years) were followed up 25 years later (aged 31-41 years). Childhood measures (weight, height and skinfolds) were collected in 1985. Body mass index (BMI), overweight status and fat mass were calculated. Participants underwent 1.5 T knee magnetic resonance imaging (MRI) during 2008-2010, and cartilage defects and BMLs were scored from knee MRI scans. Log binomial regressions were used to examine the associations.Results: Among 327 participants (47.1% females), 21 (6.4%) were overweight in childhood. Childhood adiposity measures were associated with the increased risk of adulthood patellar cartilage defects (Weight relative risk (RR) 1.05/kg, 95% confidence interval (CI) 1.01-1.09; BMI 1.10/kg/m2, 1.01-1.19; Overweight 2.22/yes, 1.21-4.08; fat mass 1.11/kg, 1.01-1.22), but not tibiofemoral cartilage defects. Childhood adiposity measures were not significantly associated with adulthood knee BMLs except for the association between childhood overweight status and adulthood patellar BMLs (RR 2.87/yes, 95% CI 1.10-7.53). These significant associations persisted after adjustment for corresponding adulthood adiposity measure.Conclusion: Childhood adiposity measures were associated with the increased risk of adulthood patellar cartilage defects and, to a lesser extent, BMLs, independent of adulthood adiposity measures. These results suggest that adiposity in childhood has long-term effects on patellar structural abnormalities in young adults.

Item Type: Article
Authors/Creators:Meng, T and Thayer, S and Venn, A and Wu, F and Cicuttini, F and March, L and Dwyer, T and Halliday, A and Cross, M and Laslett, LL and Jones, G and Ding, C and Antony, B
Keywords: childhood, adiposity, cartilage defects, bone marrow lesions
Journal or Publication Title: Osteoarthritis and Cartilage
Publisher: W B Saunders Co Ltd
ISSN: 1063-4584
DOI / ID Number: 10.1016/j.joca.2018.05.008
Copyright Information:

© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/

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