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Late gestation immune activation increases IBA1-positive immunoreactivity levels in the corpus callosum of adult rat offspring

Duchatel, RJ, Meehan, CL, Harms, LR, Michie, PT, Bigland, MJ, Smith, DW, Walker, FR, Jobling, P, Hodgson, DM and Tooney, PA 2018 , 'Late gestation immune activation increases IBA1-positive immunoreactivity levels in the corpus callosum of adult rat offspring' , Psychiatry research , pp. 175-185 , doi: 10.1016/j.psychres.2018.05.063.

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Abstract

Animal models of maternal immune activation study the effects of infection, an environmental risk factor forschizophrenia, on brain development. Microglia activation and cytokine upregulation may have key roles inschizophrenia neuropathology. We hypothesised that maternal immune activation induces changes in microgliaand cytokines in the brains of the adult offspring. Maternal immune activation was induced by injecting polyriboinosinic:polyribocytidylicacid into pregnant rats on gestational day (GD) 10 or GD19, with brain tissuecollected from the offspring at adulthood. We observed no change in Iba1, Gfap, IL1-βand TNF-α mRNA levels inthe cingulate cortex (CC) in adult offspring exposed to maternal immune activation. Prenatal exposure to immuneactivation had a significant main effect on microglial IBA1-positive immunoreactive material (IBA1+IRM)in the corpus callosum; post-hoc analyses identified a significant increase in GD19 offspring, but not GD10. Nochange in was observed in the CC. In contrast, maternal immune activation had a significant main effect on GFAP+IRM in the CC at GD19 (not GD10); post-hoc analyses only identified a strong trend towards increased GFAP+IRM in the GD19 offspring, with no white matter changes. This suggests late gestation maternal immuneactivation causes subtle alterations to microglia and astrocytes in the adult offspring.

Item Type: Article
Authors/Creators:Duchatel, RJ and Meehan, CL and Harms, LR and Michie, PT and Bigland, MJ and Smith, DW and Walker, FR and Jobling, P and Hodgson, DM and Tooney, PA
Keywords: Schizophrenia, Microglia, astrocyte, Maternal immune activation, Cingulate cortex, Late gestation, Rat
Journal or Publication Title: Psychiatry research
Publisher: Elsevier Sci Ireland Ltd
ISSN: 0165-1781
DOI / ID Number: 10.1016/j.psychres.2018.05.063
Copyright Information:

Crown Copyright 2018 Published by Elsevier B.V. All rights reserved.

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