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Abstract

Aims: The relationship between life-course body mass index (BMI) trajectories and adult risk for cardiovascular disease (CVD) is poorly described. In a longitudinal cohort, we describe BMI trajectories from early childhood to adulthood and investigate their association with CVD risk factors [Type 2 diabetes mellitus (T2DM), high-risk lipid levels, hypertension, and high carotid intima-media thickness (cIMT)] in adulthood (34-49 years).Methods and results: Six discrete long-term BMI trajectories were identified using latent class growth mixture modelling among 2631 Cardiovascular Risk in Young Finns Study participants (6-49 years): stable normal (55.2%), resolving (1.6%), progressively overweight (33.4%), progressively obese (4.2%), rapidly overweight/obese (4.3%), and persistent increasing overweight/obese (1.2%). Trajectories of worsening or persisting obesity were generally associated with increased risk of CVD outcomes in adulthood (24-49 years) [all risk ratios (RRs) >15, P Conclusion: The long-term BMI trajectories that reach or persist at high levels associate with CVD risk factors in adulthood. Stabilizing BMI in obese adults and resolving elevated child BMI by adulthood might limit and reduce adverse cardiometabolic profiles. However, efforts to prevent child obesity might be most effective to reduce the risk for adult atherosclerosis.

Item Type:	Article
Authors/Creators:	Buscot, MJ and Thomson, RJ and Juonala, M and Sabin, MA and Burgner, DP and Lehtimaki, T and Hutri-Kahonen, N and Viikari, JSA and Raitakari, OT and Magnussen, CG
Keywords:	cardiovascular risk, BMI, long-term trajectories, obesity, childhood to adulthood
Journal or Publication Title:	European Heart Journal
Publisher:	W B Saunders Co Ltd
ISSN:	0195-668X
DOI / ID Number:	10.1093/eurheartj/ehy161
Copyright Information:	Copyright 2018 The Authors. This is a pre-copyedited, author-produced version of an article accepted for publication in European Heart Journal following peer review. The version of record is available online at: http://dx.doi.org/10.1093/eurheartj/ehy161
Related URLs:	Google Scholar: Buscot, MJ Google Scholar: Magnussen, CG UTAS Profile: Magnussen, CG
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