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Regulation and sensing of inflammasomes and their impact on intestinal health

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Ranson, NM, Kunde, D ORCID: 0000-0002-6513-032X and Eri, R ORCID: 0000-0003-1688-8043 2017 , 'Regulation and sensing of inflammasomes and their impact on intestinal health' , International Journal of Molecular Sciences, vol. 18, no. 11 , pp. 1-19 , doi: 10.3390/ijms18112379.

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Abstract

Pattern recognition receptors such as nucleotide-binding oligomerization domain(NOD)-containing protein receptors (NLRs) and the pyrin and hematopoitic interferon-induciblenuclear protein (HIN) domain (PYHIN) receptors initiate the inflammatory response followingcell stress or pathogenic challenge. When activated, some of these receptors oligomerize to formthe structural backbone of a signalling platform known as an inflammasome. Inflammasomes promotethe activation of caspase-1 and the maturation of the proinflammatory cytokines, interleukin (IL)-1βand IL-18. The gut dysregulation of the inflammasome complex is thought to be a contributingfactor in the development of inflammatory bowel diseases (IBD), such as ulcerative colitis (UC)and Crohn’s disease (CD). The importance of inflammasomes to intestinal health has been emphasizedby various inflammasome-deficient mice in dextran sulphate sodium (DSS) models of intestinalinflammation and by the identification of novel potential candidate genes in population-basedhuman studies. In this review, we summarise the most recent findings with regard to the formation,sensing, and regulation of the inflammasome complex and highlight their importance in maintainingintestinal health.

Item Type: Article
Authors/Creators:Ranson, NM and Kunde, D and Eri, R
Keywords: inflammasomes; ulcerative colitis; Crohn’s disease; interleukin (IL)-1β; IL-18
Journal or Publication Title: International Journal of Molecular Sciences
Publisher: MDPI
ISSN: 1661-6596
DOI / ID Number: 10.3390/ijms18112379
Copyright Information:

© 2017 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

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