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Vitamin D supplementation and inflammatory and metabolic biomarkers in patients with knee osteoarthritis: post hoc analysis of a randomised controlled trial

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Zheng, S, Wang, B, Han, W ORCID: 0000-0003-1590-7433, Zhu, Z ORCID: 0000-0003-3913-2564, Wang, X, Jin, X, Antony, B ORCID: 0000-0001-8704-6084, Cicuttini, F, Wluka, A, Winzenberg, T ORCID: 0000-0002-4112-3491, Aitken, D ORCID: 0000-0001-5685-7634, Blizzard, L ORCID: 0000-0002-9541-6943, Jones, G ORCID: 0000-0002-9814-0006 and Ding, C ORCID: 0000-0002-9479-730X 2018 , 'Vitamin D supplementation and inflammatory and metabolic biomarkers in patients with knee osteoarthritis: post hoc analysis of a randomised controlled trial' , The British journal of nutrition, vol. 120, no. 1 , pp. 41-48 , doi: 10.1017/S0007114518001174.

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Abstract

The aim of this study was to determine whether vitamin D supplementation and maintaining vitamin D sufficiency are associated with changesin inflammatory and metabolic biomarkers in patients with knee osteoarthritis (OA) and vitamin D deficiency. A total of 413 participants withsymptomatic knee OA and vitamin D deficiency were enrolled in a randomised, placebo-controlled trial and received 1·25 mg vitamin D3 orplacebo monthly for 24 months across two sites. In this post hoc analysis, 200 participants from one site (ninety-four from the placebo groupand 106 from the vitamin D group; mean age 63·1 (SD 7·3) years, 53·3% women) were randomly selected for measurement of serum levels ofinflammatory and metabolic biomarkers at baseline and 24 months using immunoassays. In addition, participants were classified into twogroups according to serum 25-hydroxyvitamin D (25(OH)D) levels at months 3 and 24: (1) not consistently sufficient (25(OH)D≤50 nmol/l ateither month 3 or 24, n 61), and (2) consistently sufficient (25(OH)D >50 nmol/l at both months 3 and 24, n 139). Compared with placebo,vitamin D supplementation had no significant effect on change in serum high-sensitive C-reactive protein, IL-6, IL-8, IL-10, leptin, adiponectin,resistin, adipsin and apelin. Being consistently vitamin D sufficient over 2 years was also not associated with changes in these biomarkerscompared with not being consistently sufficient. Vitamin D supplementation and maintaining vitamin D sufficiency did not alter serum levelsof inflammatory and metabolic biomarkers over 2 years in knee OA patients who were vitamin D insufficient, suggesting that they may notaffect systemic inflammation in knee OA patients.

Item Type: Article
Authors/Creators:Zheng, S and Wang, B and Han, W and Zhu, Z and Wang, X and Jin, X and Antony, B and Cicuttini, F and Wluka, A and Winzenberg, T and Aitken, D and Blizzard, L and Jones, G and Ding, C
Keywords: vitamin D, inflammation
Journal or Publication Title: The British journal of nutrition
Publisher: C A B I Publishing
ISSN: 0007-1145
DOI / ID Number: 10.1017/S0007114518001174
Copyright Information:

Copyright 2018 The Authors

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