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Therapeutic potential of enoxaparin in Lichen planus: exploring reasons for inconsistent reports

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Patel, RP ORCID: 0000-0001-9344-1013, Shastri, MD ORCID: 0000-0002-1012-2779, Ming, LC ORCID: 0000-0002-6971-1383, Zaidi, STR ORCID: 0000-0002-2031-1055 and Peterson, GM ORCID: 0000-0002-6764-3882 2018 , 'Therapeutic potential of enoxaparin in Lichen planus: exploring reasons for inconsistent reports' , Frontiers in Pharmacology, vol. 9 , pp. 1-10 , doi: 10.3389/fphar.2018.00586.

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Abstract

Lichen planus (LP) is an uncommon mucocutaneous inflammatory condition, that is immunologically mediated, typically pruritic and often recurs. The currently advocated therapies are either not highly effective or associated with severe side effects. Enoxaparin, a widely used anticoagulant, is composed of both anticoagulant and non-anticoagulant fragments. Enoxaparin is reported to have anti-inflammatory properties and it was found to be effective in LP. However, the results from clinical studies have varied substantially and, therefore, the clinical role of enoxaparin in LP remains uncertain. This review focuses on potential reasons for the reported inconsistent outcomes, as well as proposing solutions; these include identifying batch-to-batch inconsistency in the composition of enoxaparin. The potential therapeutic value of enoxaparin in LP must be explored using well-designed clinical trials, combined with experimental studies that focus on identifying the anti-inflammatory fragments of enoxaparin and elucidating the mechanism of action of these non-anticoagulant fragments.

Item Type: Article
Authors/Creators:Patel, RP and Shastri, MD and Ming, LC and Zaidi, STR and Peterson, GM
Keywords: Lichen planus enoxaparin heparin
Journal or Publication Title: Frontiers in Pharmacology
Publisher: Frontiers Research Foundation
ISSN: 1663-9812
DOI / ID Number: 10.3389/fphar.2018.00586
Copyright Information:

Copyright 2018 Patel, Shastri, Ming, Zaidi and Peterson. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

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