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The cascading pathogenic consequences of Sarcoptes scabiei infection that manifest in host disease

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Martin, AM ORCID: 0000-0002-6603-2385, Fraser, TA ORCID: 0000-0001-7960-2458, Lesku, JA, Simpson, K, Roberts, GL, Garvey, J, Polkinghorne, A, Burridge, CP ORCID: 0000-0002-8185-6091 and Carver, S ORCID: 0000-0002-3579-7588 2018 , 'The cascading pathogenic consequences of Sarcoptes scabiei infection that manifest in host disease' , Royal Society Open Science, vol. 5 , pp. 1-14 , doi: 10.1098/rsos.180018.

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Abstract

Sarcoptic mange, caused by the parasitic mite Sarcoptes scabiei, causes a substantive burden of disease to humans, domestic animals and wildlife, globally. There are many effects of S. scabiei infection, culminating in the disease which hosts suffer. However, major knowledge gaps remain on the pathogenic impacts of this infection. Here, we focus on the bare-nosed wombat host (Vombatus ursinus) to investigate the effects of mange on: (i) host heat loss and thermoregulation, (ii) field metabolic rates, (iii) foraging and resting behaviour across full circadian cycles, and (iv) fatty acid composition in host adipose, bone marrow, brain and muscle tissues. Our findings indicate that mange-infected V. ursinus lose more heat to the environment from alopeciaaffected body regions than healthy individuals. Additionally, mange-infected individuals have higher metabolic rates in the wild. However, these metabolic demands are difficult to meet, because infected individuals spend less time foraging and more time inactive relative to their healthy counterparts, despite being outside of the burrow for longer.

Item Type: Article
Authors/Creators:Martin, AM and Fraser, TA and Lesku, JA and Simpson, K and Roberts, GL and Garvey, J and Polkinghorne, A and Burridge, CP and Carver, S
Keywords: mange, disease, physiology, Vombatus ursinus, sarcoptic mange, pathophysiology, metabolic rate, fatty acid composition, time budget
Journal or Publication Title: Royal Society Open Science
Publisher: The Royal Society Publishing
ISSN: 2054-5703
DOI / ID Number: 10.1098/rsos.180018
Copyright Information:

© 2018 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

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