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The Role of Epithelial-Mesenchymal Transition in Chronic Obstructive Pulmonary Disease

Courtney, J-M ORCID: 0000-0003-4461-4197 and Spafford, PL ORCID: 0000-0002-6990-9680 2017 , 'The Role of Epithelial-Mesenchymal Transition in Chronic Obstructive Pulmonary Disease' , Cells Tissues Organs, vol. 203, no. 2 , pp. 99-104 , doi: 10.1159/000450919.

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Abstract

Chronic obstructive pulmonary disease (COPD) is a major cause of mortality worldwide, and there is currently no treatment that can halt the progression of the disease. Over the last decade there has been increasing interest in the idea that epithelial-mesenchymal transition (EMT) may be active in COPD. Here we review the evidence for EMT in COPD as well as the current progress being made on understanding the drivers and mechanisms involved. Finally, we discuss the potential benefits that understanding EMT may bring to the field of chronic respiratory disease.

Item Type: Article
Authors/Creators:Courtney, J-M and Spafford, PL
Keywords: epithelial-mesenchymal transition, chronic obstructive pulmonary disease, cigarette smoke, nicotine, airway epithelium
Journal or Publication Title: Cells Tissues Organs
Publisher: Karger
ISSN: 1422-6405
DOI / ID Number: 10.1159/000450919
Copyright Information:

© 2017 S. Karger AG, Basel

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