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The importance of synovial inflammation in osteoarthritis: current evidence from imaging assessments and clinical trials

Wang, X, Hunter, DJ, Jin, X and Ding, C ORCID: 0000-0002-9479-730X 2018 , 'The importance of synovial inflammation in osteoarthritis: current evidence from imaging assessments and clinical trials' , Osteoarthritis and Cartilage, vol. 26, no. 2 , pp. 165-174 , doi: 10.1016/j.joca.2017.11.015.

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Abstract

Synovial abnormalities have been observed at multiple stages of osteoarthritis (OA). Increasing evidence suggests that it may play an important role in the OA pathological process. Many assessment systems using magnetic resonance imaging (MRI) and ultrasound have been established to detect synovial inflammation in OA. These have been used to inform the current investigation of OA disease phenotypes and progression and can be utilised in the future for clinical trials developing potential treatments. This narrative review aims to illustrate the importance of synovial tissue in OA and provide an overview of imaging assessments and possible therapies targeting synovial abnormalities.

Item Type: Article
Authors/Creators:Wang, X and Hunter, DJ and Jin, X and Ding, C
Keywords: synovial inflammation, osteoarthritis, magnetic resonance imaging
Journal or Publication Title: Osteoarthritis and Cartilage
Publisher: W B Saunders Co Ltd
ISSN: 1063-4584
DOI / ID Number: 10.1016/j.joca.2017.11.015
Copyright Information:

© 2017 Osteoarthritis Research Society International. Published by Elsevier Ltd.

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