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The interaction between vitamin D receptor polymorphisms and sun exposure around time of diagnosis influences melanoma survival

Orlow, I, Shi, Y, Kanetsky, PA, Thomas, NE, Luo, L, Corrales-Guerrero, S, Cust, AE, Sacchetto, L, Zanetti, R, Rosso, S, Armstrong, BK, Dwyer, T, Venn, A ORCID: 0000-0001-7090-1398, Gallagher, RP, Gruber, SB, Marrett, LD, Anton-Culver, H, Busam, K, Begg, CB and Berwick, M 2017 , 'The interaction between vitamin D receptor polymorphisms and sun exposure around time of diagnosis influences melanoma survival' , Pigment Cell and Melanoma Research , pp. 1-10 , doi: 10.1111/pcmr.12653.

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Abstract

Evidence on the relationship between the vitamin D pathway and outcomes in melanoma is growing, although it is not always clear. We investigated the impact of measured levels of sun exposure at diagnosis on associations of vitamin D receptor gene (VDR) polymorphisms and melanoma death in 3336 incident primary melanoma cases. Interactions between six SNPs and a common 3'-end haplotype were significant (p VDR and melanoma-specific survival is modified by sun exposure around diagnosis, and require validation in an independent study. Whether the observed effects are dependent or independent of vitamin D activation remains to be determined.

Item Type: Article
Authors/Creators:Orlow, I and Shi, Y and Kanetsky, PA and Thomas, NE and Luo, L and Corrales-Guerrero, S and Cust, AE and Sacchetto, L and Zanetti, R and Rosso, S and Armstrong, BK and Dwyer, T and Venn, A and Gallagher, RP and Gruber, SB and Marrett, LD and Anton-Culver, H and Busam, K and Begg, CB and Berwick, M
Keywords: exposure, haplotype, interaction, melanoma, polymorphism, SNP, survival, UVB, vitamin D receptor
Journal or Publication Title: Pigment Cell and Melanoma Research
Publisher: Wiley-Blackwell Publishing, Inc.
ISSN: 1755-1471
DOI / ID Number: 10.1111/pcmr.12653
Copyright Information:

Copyright 2017 John Wiley & Sons A/S

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