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Associations between knee structural measures, circulating inflammatory factors and MMP13 in patients with knee osteoarthritis

Ruan, G, Xu, J, Wang, K, Wu, J, Zhu, Q, Ren, J, Bian, F, Chang, B, Bai, X, Han, W ORCID: 0000-0003-1590-7433 and Ding, C ORCID: 0000-0002-9479-730X 2018 , 'Associations between knee structural measures, circulating inflammatory factors and MMP13 in patients with knee osteoarthritis' , Osteoarthritis and Cartilage, vol. 26, no. 8 , pp. 1063-1069 , doi: 10.1016/j.joca.2018.05.003.

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Abstract

Objective: To investigate cross-sectional associations between serum level of Matrix metalloproteinase (MMP)13 and knee structural measures and circulating inflammatory factors in patients with symptomatic knee osteoarthritis (OA).Design: A total of 149 subjects with symptomatic knee OA were included. Magnetic resonance imaging was used to measure infrapatellar fat pad (IPFP) volume, IPFP signal intensity alternation, cartilage volume and cartilage defects. Knee radiography was used to assess radiographic OA using the Kellgren-Lawrence (K-L) grading system. Enzyme-linked immunosorbent assay was used to measure the serum levels of inflammatory factors and MMP13.Results: In multivariable analyses, serum MMP13 was negatively associated with cartilage volume at patellar site (β: -32.94 mm3 per 10 ng/ml, P P P 3 per 10 ng/ml, P P P Conclusions: Serum level of MMP13 was associated with knee structural abnormalities as well as serum inflammatory factors. These suggest that systemic MMP13 may play a role in knee OA, and could be regulated by inflammatory factors.

Item Type: Article
Authors/Creators:Ruan, G and Xu, J and Wang, K and Wu, J and Zhu, Q and Ren, J and Bian, F and Chang, B and Bai, X and Han, W and Ding, C
Keywords: inflammatory factors, magnetic resonance imaging, matrix metalloproteinases 13, osteoarthritis
Journal or Publication Title: Osteoarthritis and Cartilage
Publisher: W B Saunders Co Ltd
ISSN: 1063-4584
DOI / ID Number: 10.1016/j.joca.2018.05.003
Copyright Information:

© 2018 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

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