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Abstract

Objectives: This study sought to identify whether impaired global longitudinal strain (GLS), diastolic dysfunction (DD), or left atrial enlargement (LAE) should be added to stage B heart failure (SBHF) criteria in asymptomatic patients with type 2 diabetes mellitus.Background: SBHF is a precursor to clinical heart failure (HF), and its recognition justifies initiation of cardioprotective therapy. However, original definitions of SBHF were based on LV hypertrophy and impaired ejection fraction.Methods: Patients with asymptomatic type 2 diabetes mellitus ≥65 years-of-age (age 71 ± 4 years; 55% men) with preserved ejection fraction and no ischemic heart disease were recruited from a community-based population. All underwent a standard clinical evaluation, and a comprehensive echocardiogram, including assessment of left ventricular hypertrophy (LVH), LAE, DD (abnormal E/e'), and GLS (Results: In this asymptomatic group, LV dysfunction was identified in 30 (10%) by DD, 68 (23%) by LVH, 102 (35%) by LAE, and 68 (23%) by impaired GLS. New-onset HF developed in 45 patients and 4 died, giving an event rate of 112/1,000 person-years. Survival free of the composite endpoint (HF and death) was about 1.5-fold higher in patients without a normal, compared with an abnormal echocardiogram. LVH, LAE, and GLS Conclusions: Subclinical left ventricular systolic dysfunction is prevalent in asymptomatic elderly patients with type 2 diabetes mellitus, and impaired GLS is independent and incremental to LVH in the prediction of incident HF.

Item Type:	Article
Authors/Creators:	Wang, Y and Yang, H and Huynh, Q and Nolan, MT and Negishi, K and Marwick, TH
Keywords:	T2DM, community, echocardiography, global longitudinal strain, stage B heart failure, subclinical LV dysfunction
Journal or Publication Title:	JACC: Cardiovascular Imaging
Publisher:	Elsevier Inc.
ISSN:	1936-878X
DOI / ID Number:	10.1016/j.jcmg.2018.03.015
Copyright Information:	© 2018 by the American College of Cardiology Foundation.
Related URLs:	UTAS Profile: Huynh, Q Google Scholar: Negishi, K UTAS Profile: Negishi, K UTAS Profile: Marwick, TH
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