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Success in achieving the targets of the 20-Year Infancy-Onset Dietary Intervention: association with insulin sensitivity and serum lipids

Laitinen, TT, Nuotio, J, Juonala, M, Niinikoski, H, Rovio, S, Viikari, JSA, Ronnemaa, T, Magnussen, CG ORCID: 0000-0002-6238-5730, Jokinen, E, Lagstrom, H, Jula, A, Simell, O, Raitakari, OT and Pahkala, K 2018 , 'Success in achieving the targets of the 20-Year Infancy-Onset Dietary Intervention: association with insulin sensitivity and serum lipids' , Diabetes Care , pp. 1-9 , doi: 10.2337/dc18-0869.

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Abstract

Objective: We examined whether success in achieving the key targets of an infancy-onset 20-year dietary intervention associated with insulin sensitivity and serum lipids from early childhood to young adulthood.Research Design and Methods: The sample comprised 941 children participating in the prospective, randomized Special Turku Coronary Risk Factor Intervention Project (STRIP). Dietary counseling was given biannually based on the Nordic Nutrition Recommendations with the main aim to improve the quality of dietary fat in children's diets and the secondary aim to promote intake of vegetables, fruits, and whole-grain products. Food records and serum lipid profile were studied annually from 1 to 20 years of age, and HOMA of insulin resistance (HOMA-IR) was assessed between 7 and 20 years of age. Meeting the intervention targets for quality of dietary fat was defined as the ratio of saturated fatty acids (SAFA) to monounsaturated and polyunsaturated fatty acids (MUFA + PUFA) Results: Participants in the intervention group had a higher probability of meeting the targets of SAFA/(PUFA + MUFA) 3 g/MJ (RR 1.37 [95% CI 1.04-1.80]). Participants who achieved more targets had lower HOMA-IR, lower concentrations of fasting serum glucose, insulin, LDL cholesterol, and non-HDL cholesterol, and a lower ratio of apolipoprotein (Apo) B/ApoA1 (P values all ≤0.003).Conclusions: Achieving the key targets of an infancy-onset 20-year dietary intervention was associated with better insulin sensitivity and serum lipid profile throughout the early life course.

Item Type: Article
Authors/Creators:Laitinen, TT and Nuotio, J and Juonala, M and Niinikoski, H and Rovio, S and Viikari, JSA and Ronnemaa, T and Magnussen, CG and Jokinen, E and Lagstrom, H and Jula, A and Simell, O and Raitakari, OT and Pahkala, K
Journal or Publication Title: Diabetes Care
Publisher: Amer Diabetes Assoc
ISSN: 0149-5992
DOI / ID Number: 10.2337/dc18-0869
Copyright Information:

Copyright 2018 by the American Diabetes Association

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