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Beta2‐adrenoceptor agonist salbutamol increases protein turnover rates and alters signalling in skeletal muscle after resistance exercise in young men

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Hostrup, M, Reitelseder, S, Jessen, S, Kalsen, A, Nyberg, M, Egelund, J, Kreiberg, M, Kristensen, CM, Thomassen, M, Pilegaard, H, Backer, V, Jacobson, GA ORCID: 0000-0002-3409-8769, Holm, L and Bangsbo, J 2018 , 'Beta2‐adrenoceptor agonist salbutamol increases protein turnover rates and alters signalling in skeletal muscle after resistance exercise in young men' , Journal of Physiology, vol. 596, no. 17 , pp. 4121-4139 , doi: 10.1113/JP275560.

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Abstract

The effect of beta2-adrenoceptor stimulation on skeletal muscle protein turnover andintracellular signalling is insufficiently explored in humans, particularly in association withexercise. In a randomized placebo-controlled crossover study with 12 trained men, the effectof beta2-agonist (6×4 mg oral salbutamol) on protein turnover rates, intracellular signalling,and mRNA response in skeletal muscle was investigated 0.5-5 h after quadriceps resistanceexercise. Each trial was preceded by a four-day lead-in treatment period. Leg protein turnoverrates were assessed by infusion of [13C6]-phenylalanine and sampling of arterial and venousblood as well as vastus lateralis muscle biopsies 0.5 and 5 h after exercise. Furthermore,myofibrillar fractional synthesis rate (FSR), intracellular signalling and mRNA response weremeasured in muscle biopsies. Mean (±95%CI) myofibrillar FSR was higher for salbutamolthan placebo [0.079(±0.007) vs. 0.066(±0.004)%×h-1](p1×100 gLeg Lean Mass-1higher forsalbutamol than placebo (ppp<0.01)for salbutamol 5 h after. These observations suggest that beta2-agonist increases proteinturnover rates in skeletal muscle after resistance exercise in humans, with concomitantcAMP/PKA and Akt2 signalling, and modulation of mRNA response of growth-regulatingproteins.

Item Type: Article
Authors/Creators:Hostrup, M and Reitelseder, S and Jessen, S and Kalsen, A and Nyberg, M and Egelund, J and Kreiberg, M and Kristensen, CM and Thomassen, M and Pilegaard, H and Backer, V and Jacobson, GA and Holm, L and Bangsbo, J
Keywords: beta2-agonist salbutamol muscle doping
Journal or Publication Title: Journal of Physiology
Publisher: Cambridge Univ Press
ISSN: 0022-3751
DOI / ID Number: 10.1113/JP275560
Copyright Information:

Copyright 2018 The Authors. The Journal of Physiology Copyright 2018 The Physiological Society

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