Open Access Repository
Beta2‐adrenoceptor agonist salbutamol increases protein turnover rates and alters signalling in skeletal muscle after resistance exercise in young men
Altmetric
Altmetric
ORCID: 0000-0002-3409-8769, Holm, L and Bangsbo, J 2018
, 'Beta2‐adrenoceptor agonist salbutamol increases protein turnover rates and alters signalling in skeletal muscle after resistance exercise in young men'
, Journal of Physiology, vol. 596, no. 17
, pp. 4121-4139
, doi: https://doi.org/10.1113/JP275560.
|
PDF
Hostrup_et_al-2...pdf | Download (1MB) | Preview |
Abstract
The effect of beta2-adrenoceptor stimulation on skeletal muscle protein turnover andintracellular signalling is insufficiently explored in humans, particularly in association withexercise. In a randomized placebo-controlled crossover study with 12 trained men, the effectof beta2-agonist (6×4 mg oral salbutamol) on protein turnover rates, intracellular signalling,and mRNA response in skeletal muscle was investigated 0.5-5 h after quadriceps resistanceexercise. Each trial was preceded by a four-day lead-in treatment period. Leg protein turnoverrates were assessed by infusion of [13C6]-phenylalanine and sampling of arterial and venousblood as well as vastus lateralis muscle biopsies 0.5 and 5 h after exercise. Furthermore,myofibrillar fractional synthesis rate (FSR), intracellular signalling and mRNA response weremeasured in muscle biopsies. Mean (±95%CI) myofibrillar FSR was higher for salbutamolthan placebo [0.079(±0.007) vs. 0.066(±0.004)%×h-1](p1×100 gLeg Lean Mass-1higher forsalbutamol than placebo (ppp<0.01)for salbutamol 5 h after. These observations suggest that beta2-agonist increases proteinturnover rates in skeletal muscle after resistance exercise in humans, with concomitantcAMP/PKA and Akt2 signalling, and modulation of mRNA response of growth-regulatingproteins.
| Item Type: | Article |
|---|---|
| Authors/Creators: | Hostrup, M and Reitelseder, S and Jessen, S and Kalsen, A and Nyberg, M and Egelund, J and Kreiberg, M and Kristensen, CM and Thomassen, M and Pilegaard, H and Backer, V and Jacobson, GA and Holm, L and Bangsbo, J |
| Keywords: | beta2-agonist salbutamol muscle doping |
| Journal or Publication Title: | Journal of Physiology |
| Publisher: | Cambridge Univ Press |
| ISSN: | 0022-3751 |
| DOI / ID Number: | https://doi.org/10.1113/JP275560 |
| Copyright Information: | Copyright 2018 The Authors. The Journal of Physiology Copyright 2018 The Physiological Society |
| Related URLs: | |
| Item Statistics: | View statistics for this item |
Actions (login required)
 |
Item Control Page |