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Association of depression with mortality in an elderly treated hypertensive population

Chowdhury, EK, Berk, M, Nelson, MR ORCID: 0000-0001-9941-7161, Wing, LMH and Reid, CM 2018 , 'Association of depression with mortality in an elderly treated hypertensive population' , International Psychogeriatrics , pp. 1-11 , doi:

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Background: Both elevated blood pressure and/or depression increase the risk of cardiovascular disease and mortality. This study in treated elderly hypertensive patients explored the incidence of depression, its association (pre-existing and incident) with mortality and predictors of incident depression.Methods: Data from 6,083 hypertensive patients aged ≥65 years enrolled in the Second Australian National Blood Pressure study were used. Participants were followed for a median of 10.8 years (including 4.1 years in-trial) and classified into: "no depression," "pre-existing" and "incident" depression groups based on either being "diagnosed with depressive disorders" and/or "treated with an anti-depressant drug" at baseline or during in-trial period. Further, we redefined "depression" restricted to presence of both conditions for sensitivity analyses. For the current study, end-points were all-cause and any cardiovascular mortality.Results: 313 (5%) participants had pre-existing depression and a further 916 (15%) participants developed depression during the trial period (incidence 4% per annum). Increased (hazard-ratio, 95% confidence-interval) all-cause mortality was observed among those with either pre-existing (1.23, 1.01-1.50; p = 0.03) or incident (1.26, 1.12-1.41; p Conclusions: This elderly cohort had a high incidence of depression irrespective of their randomised antihypertensive regimen. Both pre-existing and incident depression were associated with increased mortality.

Item Type: Article
Authors/Creators:Chowdhury, EK and Berk, M and Nelson, MR and Wing, LMH and Reid, CM
Keywords: angiotensin converting enzyme inhibitors, depression, diuretics, elderly, hypertension, survival
Journal or Publication Title: International Psychogeriatrics
Publisher: Springer Publishing Co
ISSN: 1041-6102
DOI / ID Number:
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Copyright 2018 International Psychogeriatric Association

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