Open Access Repository

The interactive effect of physical activity and APOE-Ɛ4 on cognitive function in older adults

Marris-Smith, RL ORCID: 0000-0003-4398-4268 2017 , 'The interactive effect of physical activity and APOE-Ɛ4 on cognitive function in older adults', Honours thesis, University of Tasmania.

Full text not available from this repository.


The purpose of this study was to examine the relationship between physical activity (PA) and the APOE-Ɛ4 on cognitive functioning in cognitively normal older adults. Two hundred participants (mean age = 64.35 years old, male N = 61, female N = 139) estimated their average PA, underwent genetic testing, and completed a battery of neurocognitive tests assessing executive functioning, long-term memory, learning, and working memory. A cross-sectional between subjects 2 (APOE-Ɛ4 carrier status: carrier, non-carrier) x 2 (Physical activity: low, high) ANCOVA (age as covariate) was run for each cognitive test. Results revealed no significant main effects or significant interactions between PA and APOE-Ɛ4 carrier status across any cognitive domains. These results were contrary to the hypotheses. It was concluded that the protective effect of PA, and the risk effect of APOE-Ɛ4 that is present in cases of dementia may not have an effect on non-pathological cognitive decline. Future large-scale research is required to determine whether this is a true effect, or due to methodological limitations. Future research may benefit from the use of an objective measure of PA, inclusion of a measure of global cognitive functioning, and the use of a PA intervention or longitudinal design.

Item Type: Thesis - Honours
Authors/Creators:Marris-Smith, RL
Keywords: Apolipoprotein E epsilon 4; age-associated; cognitive decline; long-term memory; working memory; executive functioning
Copyright Information:

Copyright 2017 the author

Item Statistics: View statistics for this item

Actions (login required)

Item Control Page Item Control Page