Open Access Repository
Modulation of the endocannabinoid system by sex hormones: implications for Posttraumatic Stress Disorder


Full text not available from this repository.
Abstract
The endocannabinoid system is an increasingly recognised pharmacological target for treating stress and anxiety disorders, including post-traumatic stress disorder (PTSD). Recent preclinical developments have implicated the endocannabinoid system in stress responses, emotional memories and fear extinction, all critical to PTSD aetiology. However, preclinical research in endocannabinoid biology has neglected the influential role of sex hormone differences on PTSD symptomology, which is particularly important given that PTSD is twice as common in women as in men. In this review, we compile and consider the evidence that the endocannabinoid system is influenced by ovarian hormones, with application to stress disorders such as PTSD. It is clear that therapeutic modulation of the endocannabinoid system needs to be approached with awareness of ovarian hormonal influences, and knowledge of these influences may enhance treatment outcomes for female PTSD populations.
Item Type: | Article |
---|---|
Authors/Creators: | Ney, LJ and Matthews, AJ and Bruno, R and Felmingham, K |
Keywords: | cannabinoids; cannabis; endocannabinoids; oestrogens; posttraumatic stress disorder; psychiatric disorders; sex differences; translational medical research; traumatic stress |
Journal or Publication Title: | Neuroscience and Biobehavioral Reviews |
Publisher: | Pergamon-Elsevier Science Ltd |
ISSN: | 0149-7634 |
DOI / ID Number: | 10.1016/j.neubiorev.2018.07.006 |
Copyright Information: | Copyright 2018 Elsevier Ltd. |
Related URLs: | |
Item Statistics: | View statistics for this item |
Actions (login required)
![]() |
Item Control Page |