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Patient-reported outcomes are worse for progressive-onset multiple sclerosis than relapse-onset multiple sclerosis, particularly early in the disease process

Zhang, Yan ORCID: 0000-0001-9126-4922, Taylor, BV, Simpson Jr, S ORCID: 0000-0001-6521-3056, Blizzard, L ORCID: 0000-0002-9541-6943 and van der Mei, I ORCID: 0000-0001-9009-7472 2018 , 'Patient-reported outcomes are worse for progressive-onset multiple sclerosis than relapse-onset multiple sclerosis, particularly early in the disease process' , European Journal of Neurology , pp. 1-7 , doi: 10.1111/ene.13786.

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Abstract

Background and Purpose: Treatments for progressive-onset multiple sclerosis (MS) are lacking. To improve the disease management for progressive-onset MS, the differences between relapse-onset MS and progressive-onset MS in patient-reported disability, progression and symptoms were examined.Methods: A total of 1985 participants of the Australian Multiple Sclerosis Longitudinal Study were included. Associations between onset type and outcomes were assessed with negative binomial regression.Results: The severity of 17 of the 19 outcomes was significantly higher for progressive-onset MS patients than relapse-onset MS patients, including perspectives from disability, progression over the last year, fatigue, sensory, walking difficulties, pain, balance, spasticity, sexual dysfunction, bladder, bowel, anxiety, depression and the European quality of life (EQ-5D) (P Conclusion: Participants with progressive-onset MS were significantly worse off on nearly all patient-reported outcomes than relapse-onset MS participants, and the differences were most pronounced early in the disease course, highlighting the importance of early intervention for those with progressive-onset MS.

Item Type: Article
Authors/Creators:Zhang, Yan and Taylor, BV and Simpson Jr, S and Blizzard, L and van der Mei, I
Keywords: disability, onset type, patient-reported outcome, phenotype, PPMS, progressive- onset, relapse-onset, symptoms
Journal or Publication Title: European Journal of Neurology
Publisher: Blackwell Publishing Ltd
ISSN: 1351-5101
DOI / ID Number: 10.1111/ene.13786
Copyright Information:

Copyright 2018 EAN

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