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Abstract

Introduction: Unemployment is a significant problem for people with multiple sclerosis (MS). The MS WorkDifficulties Questionnaire (MSWDQ-23) is a self-report tool to assess work-related problems in people with MSacross three domains: physical, psychological/cognitive, and external barriers. The aim of this study was toassess the psychometric properties of the Spanish version of the MSWDQ-23.Methods: A multicentre, non-interventional, cross-sectional study in adult patients with relapsing-remittingmultiple sclerosis (RRMS) or primary progressive (PPMS) multiple sclerosis (McDonald 2010 criteria) wasconducted. Socio-demographic and clinical characteristics as well as health-related quality of life using the 29-item Multiple Sclerosis Impact Scale (MSIS-29) were collected.Results: A total of 201 subjects were studied (mean age: 43.9 years, 60% female, 86% with RRMS). MedianExpanded Disability Status Scale (EDSS) (score: 2.0 [IQR: 1.0–3.5]). The employment rate was 47.3% (n = 95).The MSWDQ-23 was feasible (90% response rate), with high internal consistency and test-retest reliability(Cronbach's alpha = 0.94 and intraclass correlation coefficient-ICC > 0.87). MSWDQ-23 scores significantly andpositively correlated with EDSS and both MSIS-29 physical and psychological subscales scores, showing anadequate convergent validity. Regarding construct validity, scores of patients with PPMS were higher than thoseof patients with RRMS, reaching statistically significance in MSWDQ-23 physical barriers domain and totalscores.Conclusion: The Spanish version of the MSWDQ-23 shows appropriate feasibility, reliability, and discriminativeperformance as a patient-reported outcome. MSWDQ-23 may be a valuable addition to measure the impact of acomprehensive spectrum of difficulties experienced by people with MS in the workplace.

Item Type:	Article
Authors/Creators:	Martinez-Gines, ML and Garcia-Dominguez, JM and Forero, L and Canal, N and Rebollo, P and Prefasi, D and Honan, CA and Maurino, J
Keywords:	multiple sclerosis, work difficulties, employment
Journal or Publication Title:	Multiple sclerosis and related disorders
Publisher:	Elsevier B. V.
ISSN:	2211-0356
DOI / ID Number:	10.1016/j.msard.2018.04.003
Copyright Information:	Copyright 2018 Elsevier B.V.
Related URLs:	Google Scholar: Honan, CA UTAS Profile: Honan, CA
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